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PhD Fellowship in Bacteriophage-host Interactions at Department of Veterinary and Animal Sciences

University of Copenhagen is pleased to invite applicants to apply for a new opening PhD position in medical sciences. The funds for this position are available for 3 years. Eligible candidates should submit the applications before August 23, 2020.

Our research group PHAGEBio studies the biology and applications of bacteriophages that have a natural ability to kill bacteria. The aim of our research is to elucidate novel mechanisms of phage-host interaction as well as exploiting phages and their enzymes to control pathogenic bacteria. We offer the opportunity to work in a state-of-the-art, highly innovative and scientifically stimulating environment. We value team work and consists of a group of ambitious researchers from all over the world and have a large network within the field of bacteriophages. We offer excellent training opportunities, both personally and professionally and the opportunity to contribute with new knowledge to an exciting and fast-moving scientific field. For more information see here: https://ivh.ku.dk/english/research/food_safety_and_zoonoses/phages/

The world-wide threat of antibiotic resistant bacteria has made WHO and EU emphasize the urgent need for innovative alternatives to antibiotics against Gram-negative pathogens. The aim of this project is to describe the interaction of phage tail fibers with the bacterial receptor as well as to identify novel phage resistance mechanisms. The work is part of a larger project aiming to develop and designing tail fibers targeting clinical and foodborne pathogens. This will be done by submitting a large dataset of phage-host interactions to machine learning and quantifying the efficacy of new designed tail fibers.

As a PhD fellow you will identify tail fibers of E. coli phages and determine their interaction with their cognate receptor at the protein level, taking part in the development of the training dataset to be used for prediction of phage-host interaction and tail fibers design. You will clone tail fibers from phages and test their binding on the target strains. To this aim, a period of 3-6 months in the laboratory of Sam Nugen, Cornell University, USA, is included. Furthermore, you will investigate novel phage resistance mechanisms using comparative genomic in combination with biological data on phage infection. We expect you to reveal novel understanding of phage biology and phage-host interactions and contribute to other projects running in the PHAGEBio research group. The project is funded by NIH.

We expect you to be highly motivated and ambitious and as an applicant you must have qualifications corresponding to a master's degree related to the subject area of the project e.g. bacteriophage biology, molecular microbiology, biotechnology (latest biotechnology scholarship positions) or similar. The place of employment is at Department of Veterinary and Animal Sciences Faculty of Health and Medical Sciences, University of Copenhagen. We offer creative and stimulating working conditions in a dynamic and international research environment. Our research facilities include modern laboratories and state-of-the-art equipment.

The employment as a PhD fellow is full time and for 3 years. It is conditioned upon the applicant's successful enrolment as a PhD student at the Graduate School at the Faculty of Health and Medical Sciences, University of Copenhagen. This requires submission and acceptance of an application for the specific project formulated by the applicant.

The PhD study must be completed in accordance with The Ministerial Order on the PhD programme (2013) and the Faculty's rules on achieving the degree. Salary, pension and terms of employment are in accordance with the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State. Depending on seniority, the monthly salary begins around 26.755 DKK /approx. 3.567 EUR (April 2018-level) plus pension.

For specific information about the PhD fellowship, please contact the principal supervisor. General information about PhD study at the Faculty of Health and Medical Sciences (Medical Sciences scholarships) is available at the Graduate School's website: https://healthsciences.ku.dk/phd/guidelines/

Your application must be submitted electronically by clicking 'Apply now' below. The application must include the following documents in PDF format: 2. CV incl. education, experience, language skills and other skills relevant for the position

3. Master of Science diploma and transcript of records. If not completed, a certified/signed copy of a recent transcript of records or a written statement from the institution or supervisor will do

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. The assessor makes a non-prioritized assessment of the academic qualifications and experience with respect to the above-mentioned area of research, techniques, skills and other requirements listed in the advertisement.

Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.
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