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PhD Scholarship in Targeting Cholesterol Biosynthesis and Trafficking Through Specific Protein Degradation

Applications are invited for a PhD position in sustainable development to join Technical University of Denmark. Successful candidate will have funding to work and study for 3 years in Denmark. Potential candidates should apply before July 31, 2020.

A 3-year PhD scholarship in chemical biology funded by the Novo Nordisk Foundation is available at the Department of Chemistry. The project will be under supervision of Luca Laraia and will start on November 1st 2020 or as soon as possible thereafter. The successful candidate will join a recently established, young research team, which is a part of the Chemical Biology group.

Proteolysis-targeting chimeras (PROTACs) have recently emerged as a new method to degrade proteins of interest by linking a small molecule binder to an E3 ligase ligand. The project will employ this technology to target proteins related to cholesterol biosynthesis and transport. This multi-disciplinary project is part of a larger group effort to identify new regulators of cholesterol homeostasis and will involve organic synthesis, cell biology (cell biology scholarships) and mass spectrometry-based proteomics.

The successful candidate should have a in chemistry with prior experience in synthetic organic chemistry, including standard characterization methods. Experience in cell biology would be an advantage but is not essential. However, a keen interest in applying chemical tools to solve biological problems is crucial. Most importantly, the candidate should be highly motivated, able to work independently and should be confident in both written and spoken English.

The scholarship for the PhD degree is subject to academic approval, and the candidate will be enrolled in one of the general degree programmes at DTU. For information about our enrolment requirements and the general planning of the PhD study programme, please see the DTU PhD Guide.

DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. The period of employment is 3 years.

Further questions about the project should be directed to Assistant Professor Luca Laraia, email: luclar@kemi.dtu.dk or the Head of Organic and Inorganic Chemistry (Inorganic Chemistry scholarships) Section, Professor Jens . Duus, email: jduus@kemi.dtu.dk

Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link “Apply online”, fill out the online application form, and attach all your materials in English in one PDF file. The file must include:

DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN's 17 Sustainable Development (fully funded Sustainable Development scholarships) Goals. Hans Christian rsted founded DTU in 1829 with a clear vision to develop and create value using science and engineering to benefit society. That vision lives on today. DTU has 11,500 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. Our main campus is in Kgs. Lyngby north of Copenhagen and we have campuses in Roskilde and Ballerup and in Sisimiut in Greenland.
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