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PhD Scholarship at Eindhoven University of Technology

Eindhoven University of Technology, Netherlands is inviting applicants to apply for a PhD position in neurosurgery. Applicants should apply as soon as possible.

Take your next step in research, contribute to improve care for patients with brain tumours The department of Neurosurgery (Neurosurgery scholarships) of ETZH Tilburg and TU/e Electrical Engineering offer a position as from October 2020 as PhD student (technical EE, CS)

You contribute to research that is part of the programme "A personalized care path for brain tumor patients". As a PhD student you focus on the technical AI techniques and Machine Learning algorithms for the prediction of tumor progression of vestibular schwannoma's, before and after treatment with stereotactic radiosurgery. Your tasks are as follows.

You will be part of the Video Coding & Architectures (VCA) research group the EE faculty of TU/e and cooperate with the research group of the department of Neurosurgery, which participates in the programme Highly Specialised Care & Research program 2020-2024 (Topspecialistische Zorg en Onderzoek, TZO programme; TZO; see https://www.zonmw.nl/en/research-and-results/quality-in-health-care/programmas/programme-detail/highly-specialised-care-research-programme-tzo-programme/ ), funded by ZonMw (The Netherlands (Netherlands scholarships) Organisation for Health Research and Development). The aim of this programme is to create a more personalized care path for brain tumor patients before, during and after (radio-)surgical treatment. To improve shared clinical decision making, more extensive and accurate information will be collected, and models will be developed to better predict oncological or functional outcomes after (radio)surgical treatment.

Our program has two overarching themes: Neuroimaging (eg, fMRI, DTI) and Cognition. It includes six research projects that are strongly interrelated and whereby 6 PhD candicates will jointly focus on the prediction of the outcome after treatment, each from a different perspective. Main partners are Tilburg University and Eindhoven University of Technology. In addition we are collaborating with several other national and international Universities and University Medical Centers.

The project you will be working on focuses on a benign brain tumor, called vestibular schwannoma. In practice, these tumors are treated only after growth is observed on sequential MRI's. Currently, we are unable to predict this potential growth. Therefore, multiple MRIs are necessary to monitor the behavior of the tumor. If the tumor needs to be treated, we have a strong preference to use a high-precision irradiation with the Gamma Knife. Not all tumors react in a positive way. At the moment, it is not yet possible to predict which tumors will, or will not, react positively on the treatment. The appearances on the MR images differ significantly between these tumors. The goal of this research project is to characterize these differences between tumors on the MRI with advanced image analysis (radiomics). With the use of such MRI-based data in a machine learning environment, we hope to improve the prediction of tumor progression, both before and after treatment. Improvement of prediction can lead to a clinical decision support tool, which can aid the patients and doctors to choose the optimal treatment option.

This PhD position will be jointly supervised by: Dr J. Verheul, neurosurgeon at the ETZ hospital and P. Langenhuizen (PhD upcoming) and Prof.dr. P.H.N. de With, at the Video Coding and Architectures (VCA) group, Dept. of Electrical Engineering at Eindhoven University of Technology, The Netherlands. Furthermore, there is an intensive collaboration with Prof.dr. D. Kunst at the Radboud UMC Nijmegen and international collaboration with two centers: Haukeland University Hospital Bergen, Norway, and Lausanne University Hospital, Switzerland.

The PhD candidate will be employed at Elisabeth-TweeSteden (ETZ) Hospital and regularly work at Eindhoven University of Technology.

Our offer is: Please contact Prof.dr. Peter H.N. de With ( p.h.n.de.with[at]tue.nl ) for technical details or Dr. Jeroen Verheul (j.verheul[at]etz.nl ) for more detailed project information. For general information regarding the general program, please contact Dr. Jeroen Verheul, neurosurgeon, j.verheul[at]etz.nl .

If interested, please use the 'apply now'-button at the top of this page. You should upload the following: Please note that you can upload 1 document of 10 MB. So if you have more than 1 document you will have to combine them. Screening of applications will start as soon as applications are received and will continue until the position has been filled.
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