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PhD Scholarship in Deranged Neurometabolism in Alzheimers with Hyperpolarized Magnetic Resonance

Applications are invited for a PhD position in sustainable development to join Technical University of Denmark, Denmark. Successful candidate will have funding to work and study for 3 years in Denmark. This position is closed on May 15, 2020.

Hyperpolarized Magnetic Resonance is a new medical imaging (latest medical imaging scholarship positions) modality in early clinical development that enable metabolic imaging in real-time of infused bioprobes. The method is enabled by the more than 10,000-fold enhancement of the magnetic resonance signal from nuclear spins. It offers the possibility of studying disease at the biochemical level, allowing more accurate diagnosis and treatment for the individual patient.

MR is the method of choice in brain research and clinically, due to its superior soft tissue contrast, high spatial and temporal resolution and functional contrast. In this project, we will study changes in brain metabolism in animal models with hyperpolarized MR by infusion of isotope labelled bioprobes i.e 13C-pyruvate and 13C-glucose. We hypothesize that deranged glucose metabolism is an early biomarker of Alzheimer's disease and related dementia, and our long-term goal is to develop a non-invasive, imaging tool for disease staging in patients with pre-symptomatic dementia based on hyperpolarized MR spectroscopic imaging. This will provide crucial new understanding of the disease mechanism and a clinical tool for physicians and neurologists in diagnosing and monitoring this devastating disease. In this project, we will study hyperpolarized 13C-labelled bioprobes in tauopathy mouse models of Alzheimer's disease. The bioprobes will interrogate the glycolysis (13C-glucose, 13C-pyruvate). The hyperpolarized sample preparations will be made of the bioprobes and characterized at DTU by dissolution Dynamic Nuclear Polarization and Nuclear Magnetic Resonance. We will study the bioprobes in vivo in small animal models of Alzheimer's disease at University of Queensland, Brisbane, Australia, where they will have a polarizer and small animal imaging system. HYPERMAG (hypermag.dtu.dk) is part of the Section for Magnetic Resonance ( www.cmr.healthtech.dtu.dk ) at the Department of Health Technology that conducts research in MRI and NMR. Our research is in collaboration with universities, hospitals and healthcare companies both nationally and internationally. Our main educational responsibility is within the BSc and MSc program in BioMedical Engineering in collaboration with the Faculty of Health Sciences, University of Copenhagen. You will be responsible for developing hyperpolarization protocols for the relevant bioprobes. Formulations with optimal tolerance and high polarization are important. You will receive training in the involved techniques. The in vivo studies will take place at University of Queensland, Brisbane, Australia. Thus, a longer research stay 6-12 months at UQ should be expected. UQ have mouse models of Alzheimer's Disease available, as well as the required infrastructure for hyperpolarized MR. Structural 1H MRI and hyperpolarized 13C metabolic imaging with the selected bioprobes will be performed in the animal models to test the hypothesis. You will be part of a larger team at DTU working on the hyperpolarization 13C-labelled bioprobes and technological development. You will also be part of a team at UQ with expertise in the animal models and MR imaging. You should be an outgoing person with enthusiasm, good spirit and be collaborative. Independence and drive are important qualifications. Candidates should have a two-year master’s degree (120 ECTS points) or a similar degree with an academic level equivalent to a two-year master’s degree. The preferred candidate has a degree within biomedical engineering, biology, pharmacy (pharmacy scholarships) or similar. The scholarship for the PhD degree is subject to academic approval, and the candidate will be enrolled in one of the general degree programmes at DTU. For information about our enrolment requirements and the general planning of the PhD study programme, please see the DTU PhD Guide The assessment of the applicants will be made by Professor Jan Henrik Ardenkjr-Larsen. DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility. The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. The period of employment is 3 years. Expected start date Aug 1, 2020. You can read more about Further information may be obtained from Professor Jan Ardenkjr-Larsen, tel.: +45 4525 3918. You can read more about "the Department" at www.cmr.health.dtu.dk Application Please submit your online application no later than 15 May 2020 (local time). Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link “Apply online”, fill out the online application form, and attach all your materials in English in one PDF file Excel sheet with translation of grades to the Danish grading system Candidates may apply prior to obtaining their master’s degree but cannot begin before having received it.

Applications and enclosures received after the deadline will not be considered. All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply. DTU Health Tech engages in research, education, and innovation base on technical and natural science for the healthcare sector. The Healthcare sector is a globally expanding market with demands for the most advanced technological solutions. DTU Health Tech creates the foundation for companies to develop new and innovative services and products which benefit people and create value for society. DTU Health Techs expertise spans from imaging and biosensor techniques, across digital health and biological modelling, to biopharma technologies. The department has a scientific staff of about 175 persons, 130 PhD students and a technical/administrative support staff of about 80 persons. DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN's 17 Sustainable Development (Sustainable Development scholarships) Goals. Hans Christian rsted founded DTU in 1829 with a clear vision to develop and create value using science and engineering to benefit society. That vision lives on today. DTU has 11,500 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. Our main campus is in Kgs. Lyngby north of Copenhagen and we have campuses in Roskilde and Ballerup and in Sisimiut in Greenland.
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