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Postdoc Position in Biochemistry at Imperial College London

Imperial College London, UK has an opening postdoctoral associate position in molecular biology. This position is available for two years in the first instance. Applications are invited up to April 19, 2020.

We are seeking a highly motivated Postdoctoral Research Associate to work in the Section of Molecular Microbiology, which is part of the Centre for Molecular Bacteriology and Infection (CMBI) at Imperial College London. The position is funded through the Wellcome Trust and is for two years with the possibility of extension to up to 1 January 2024.

The research project will focus on the Gram-positive bacterial pathogen Staphylococcus aureusand the work will be conducted in the state-of-the-artlaboratory ofProfessor Angelika Grndling.

The research programme will focus on understanding cellular processes that are controlled by the essential signalling nucleotide c-di-AMP in S. aureus with the long-term goal to use this knowledge to develop new methods to prevent the growth, colonization and infection with this organism. c-di-AMP is a more discovered signalling nucleotide required for the growth of S. aureus under standard growth conditions and plays an important role in osmotic regulation and cell wall homeostasis. Methicillin resistant S. aureus (MRSA) strains producing reduced levels of c-di-AMP become again sensitive to beta-lactam antibiotics. The reason for this is currently not known and this project will focus on deciphering the molecular bases for this. It is anticipated that some of this work will require a biochemical analysis of the cell wall as well as RNA-Seq analysis of WT and mutant bacteria.

Recent work from the lab has shown that while c-di-AMP is essential for growth under aerobic growth conditions, it becomes dispensable under anaerobic conditions. A second project will focus on investigating metabolic changes that occur when S. aureus growths aerobically versus anaerobically as well as provide a better understanding of essential genes under aerobic versus anaerobic growth conditions. The latter project will be done using amongst others the Tn-seq methodology.

You will have a PhD or equivalent in Microbiology, Molecular Biology, Biochemistry or a related field. You will also have knowledge in the genetic manipulation of bacteria and previous experience working with Gram-positive bacteria is desirable and previous research experience in the nucleotide signalling field is desirable. You will also have experience within an academic research environment and a proven track record with publication in relevant and peer reviewed high-quality journals.

Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range 35,477 – 38,566 per annum.

This position is offered on a full time, fixed term basis for two years with the possibility of extension to up to 1 January 2024.

Should you require any further details on the role please contact: Professor Angelika Grndling - a.grundling@imperial.ac.uk

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA),which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published.For more information, seehttps://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College's care are treated with full respect, and that all staff involved with this work show due consideration at every level. http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research/


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