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Development of New Catalytic Methods for The Efficient Construction of Natural Product-inspired 3D Scaffolds

International students are invited for a PhD scholarship in organic chemistry at The University of Nottingham. Applications are invited up to March 31, 2020.

Project Description

This PhD project aims to develop new catalytic synthetic methods for the efficient construction of natural product-inspired 3D scaffolds. The research will explore the application of recently discovered C-H and X-H bond activation using metallocarbenoids to generate SP3-rich cyclic and spirocyclic structures. The application of this methodology to the synthesis of biologically active natural and non-natural products will also be explored.

Based in the School of Chemistry, University of Nottingham, this project will provide extensive training in synthetic organic chemistry and a variety of analytical techniques (NMR, MS, HPLC, IR, UV). Furthermore, this project offers the possibility of a 3-month research placement at GlaxoSmithKline during the funded period of the PhD.

The candidate will have a degree that qualifies them for PhD study with a particular interest for organic chemistry and the development of new synthetic methods. The studentship will be filled as soon as a suitable candidate has been found, candidates are therefore encouraged to apply as soon as possible. Prospective applicants are encouraged to contact Prof C J Hayes (chris.hayes@nottingham.ac.uk) for more details about the project.

This Fully funded studentship is available to start immediately, and at the latest will commence before October 2020. UK/EU students – tuition fees paid, and full stipend at the RCUK rate (15,009 per annum (tax-free) for 2019/20).

Applicants should have, or expect to achieve, at least a 2:1 Honours degree (or equivalent) in Chemistry or closely related subject. A relevant Master’s degree that demonstrates previous research experience in synthetic chemistry and/or catalysis is an advantage.

1. “C-H Insertion as a key step to spiro-oxetanes, scaffolds for drug discovery” Nicolle, S. M.; Nortcliffe, A.; Bartrum, H. E.; Lewis, W.; Hayes C. J.; Moody, C. J. Chem. Eur. J.2017, 23, 13623-13627

2. “Stereoselective synthesis of functionalized pyrrolidines by the diverted N-H insertion reaction of metallocarbenes with -aminoketone derivatives” Nicolle, S. M.; Lewis, W.; Hayes, C. J.; Moody, C. J. Angew. Chem. Int. Ed.2016,55, 3749-3753

3. “Stereoselective synthesis of highly substituted tetrahydrofurans by diverted carbene O-H insertion reaction” Nicolle, S. M.; Hayes, C. J.; Moody, C. J. Angew. Chem. Int. Ed.2015,54, 8485-8489


Summary:

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