University of North Carolina Chapel Hill is pleased to invite applicants to apply for a new opening postdoctoral position in cell biology. Applications will be evaluated immediately.

Telomeres represent potent signaling detectors for
DNA damage in the cell, residing at the ends of our chromosomes. Containing only 1/3000th of the total
DNA in the cell, they monitor the number of cell divisions and protect us from uncontrolled cell division that can lead to cancer. Telomeres consist of a complex assembly of repetitive
DNA, cellular histone and
DNA repair factors, and
RNA transcribed from the telomeres themselves termed
TERRA. Following transcription of
TERRA, some of this
RNA remains annealed to the telomere in the form of R-loops. Unresolved R-loops represent one form of
DNA damage, yet they may play a central role in forming t-loops, a looped arrangement of the telomere in which the very
DNA end is folded back to anneal to internal telomeric sites. The goal of these studies is to use a combination of electron microscopy, light microscopy, cell biology, and biochemical methods to investigate the location, frequency and role of R-loops at the telomere. The relevance of R-loops to human disease will be a central focus. This will be done using mammalian tissue culture and cells exhibiting the
ALT phenotype. The person in this position will carry out these experiments, be engaged in collaborations with colleagues in the US and abroad and be exposed to new technologies including cryoEM.
Summary:Study in: | USA |
Level: | Postdoc |
Salary: | Unspecified |
Duration: | Unspecified |
Hours: | Full time |
Certificate: | Unspecified |
Contract: | Temporary |
Deadline: | As soon as possible |
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