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PhD Scholarship in Medical Science Estrogen Regulation of Antibodies

University of Gothenburg, Sweden is inviting applicants to apply for a PhD position in medical sciences. The initial contract for this position is four years. Applications are welcome before December 03, 2019.

At the department of Rheumatology and Inflammation Research, Inflammation is the main topic of the research conducted within the department. Our research groups perform studies of inflammatory diseases, whether caused by allergy, infection, or autoimmune disease. The goal is to investigate the mechanisms underlying the body’s tissues become inflamed. Many of our researchers are also working as a specialist physician at the clinic at Sahlgrenska University Hospital, which is also one of our greatest assets.

Project title: Estrogen regulation of antibodies and its influence on rheumatoid arthritis and bone

The PhD educationin Medical Science comprisecarrying out a scientific project and completing at least 30 credits of courses at third-cycle level. The doctoral student must also write a scientific compilation thesis or monograph corresponding to at least 120 credits. For more information about third-cycle studies at Sahlgrenska Academy, see https://medarbetarportalen.gu.se/sahlgrenskaakademin/forskarutbildning/languageId=100001

Project: Autoimmune diseases such as rheumatoid arthritis,are more common in women than in men, and the incidence increases after menopause when estrogen declines. Autoantibodies that respond to self-structures are present even beforerheumatoid arthritis breaks out ina preclinical phase and canstimulate bone loss. We have previously shown that estrogen can trigger how pathogenic antibodies can be, which means that women with autoantibodies present who enter the menopause get more easily activated antibodies that can initiate an active phase of the disease. One of the most common indirect causes of death in the western world today is fractures, which leads to reduced mobility, which in turn can lead to infections, etc. Autoantibodies and estrogen deficiency after menopause both stimulate bone degradation and present an increased risk of fractures, but the mechanism is not entirely known.

In this project, therefore, the regulation of estrogens on antibodies will be studied further in mice and also in cell cultures. Both to understand if there is a direct link to bone loss as well as estrogen-like drugs (SERM), which share the positive effects of estrogen on bones but do not stimulate uterus and breast cancer can affect how disease-causing antibodies are. This project will be performed in the Division of Rheumatology and Inflammation Research within a collaborative consortium Center for Bone and Arthritis Research (CBAR) where we among other things, look at immune regulation of bones. The primary animal studies will be followed by mechanistic studies such as, ELISA, Flow Cytometry, RT-PCR, cell and protein purification, among others. Third-cycle studies are equivalent to four year full-time and lead to a Degree of Doctor. Those appointed to doctoral studentships shall primarily devote themselves to their studies. Those appointed to doctoral studentships may, however, work to a limited extent with educational tasks, research and administration (departmental duties). Before a PhD degree has been awarded,duties of this kind may not comprise more than 20 per cent of a full-time post.

To be eligible for third-cycle studies, the applicant must meet both the general and specific entry requirements.

for third-cycle studiesif he or she:

1. has been awarded a second-cycle qualification 2. has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle, or 3. has acquired substantially equivalent knowledge in some other way in Sweden or abroad for third-cycle studiesin Medical Science if he or she: has successfully completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies

In selecting between applicants who meet the general and specific entry requirements, their ability to benefit from third-cycle studies shall be taken into account. The assessment shall attach particular importance to documented qualifications for:

– specific knowledge and skills within the subject area and related research fields – experience of scientific theory and relevant research methodology – scientific analysis and presentation verified through thesis, degree project, scientific journals or the like. Documented experiencein various immunological and metabolic methods is a merit.Experience ofwork with animal experiments is valuable.

After admission tothird-cyclestudies you will be appointedtodoctoral studentship. Regulations for employment of doctoral students are given in SFS 1993:100. The initial appointment may apply for no longer than one year. An appointment may be renewed for no more than two years at a time. A person may beappointed to a doctoral studentship for a total ofeight years. The total employment period may, however, not exceed the time corresponding to full-time third-cycle study for four years.

Location: Sahlgrenska Academy, Institute of Medicine, Department of Rheumatology and Inflammation Research.Extent:100%. First day of employment: as agreed.

Salaries for doctoral students are regulated in a local agreement at the University.

For more information about the project please contact the principal supervisor,

Cecilia Engdahl,AssociateProfessor, Institute of Medicine, phone: +46-708-892777, e-mail: cecilia.engdahl@gu.se

Union representatives at the University of Gothenburg: http://www.gu.se/english/about_the_university/job-opportunities/union-representatives

In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline.

You must include the following, in pdf format

If your degree is from a university outside of Sweden, check what you need to submit at https://www.universityadmissions.se/en/All-you-need-to-know1/Applying-for-studies/Documenting-your-eligibility-for-studies/Instructions-for-Masters-applicants/Specific-requirements-for-my-country1/ where you can also see what you need to submit in order to fulfill the English language requirement.

The University of Gothenburg promotes equal opportunities, equality and diversity.

Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.


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