Postdoc Position at Imperial College London

Applicants are invited to apply for a postdoctoral scholar position in molecular biology at Imperial College London. This fellowship is last for three years and posible to extend. Applicants should apply before September 29, 2019.

We are seeking a highly motivated Postdoctoral Research Associate to work in the Section of Molecular Microbiology, which is part of the Centre for Molecular Bacteriology and Infection (CMBI) at Imperial College London. The position is funded through the Medical Research Council for three years.

p62 is a versatile, multifunctional protein and mutations in the gene that encodes it, SQSTM1, are linked to at least four hereditary diseases. One of the best studied roles of p62 is its role as an autophagy receptor in homeostasis and antimicrobial defence. How the diverse roles of p62 are regulated remain poorly understood. Caspase-8 generates p62TRM, which has exclusive roles in nutrient-sensing.

The project will investigate the newly discovered proteolytically trimmed p62TRM in cellular signalling (Sci Signal, 2018, doi: 10.1126/scisignal.aat6903). We are broadly interested in understanding the actions of p62 and p62TRM and how natural disease-linked mutations compromise their functions. You will use cutting-edge molecular biology and cell biology tools and collaborate with an international team of clinicians as part of this study.

We are looking for a motivated and enthusiastic candidate with a PhD (or being in the final stages of completion) in Microbiology/Immunology/Cell biology or a related field. You will have experience in molecular genetic approaches in mammalian cells and eukaryotic signal transduction pathways. You will also have experience within an academic research environment and a proven track record with publications of high-quality work in relevant international peer reviewed journals.

You may be required to work with academic and clinician collaborators and should be prepared to travel off-site for short periods if necessary. You should also be prepared to supervise and provide guidance to junior members of the laboratory, including PhD students.

In addition to joining the diverse and stimulating scientific environment of the CMBI, you will have opportunities in teaching by contributing to courses for graduate and/or undergraduate students, and participating in outreach activities organised by the MRC CMBI.

This role is full-time and fixed-term for three years.

Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range 34,397 – 37,486 per annum.

Interviews are expected to be held early October 2019.

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published.For more information, see

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College's care are treated with full respect, and that all staff involved with this work show due consideration at every level.


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