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PhD Scholarships Arc Training Centre for Fragment-based Design

Applications are invited for a PhD position in medicinal chemistry to join Monash University. This position is closed on December 31, 2019.

Remuneration:Stipend value of $32,304 per annum

We are looking for highly motivated, passionate and competitive candidates for fully-funded PhD positions in the ARC Training Centre for Fragment-Based Design. Successful candidates will join the Centre, Directed by Professor Martin Scanlon, which is based at the Monash

Institute of Pharmaceutical Sciences (MIPS) at Monash University (Parkville campus).

The successful applicants will be working in a multidisciplinary research team in the new ARC Training Centre for Fragment-Based Design (CFBD), where we are working with our partners to develop small molecules that modulate protein targets involved in a range of conditions including cancer, infection, bacterial resistance and metabolic disease.

The CFBD is a collaboration between researchers at Monash University, Griffith University, and The University of Sydney. The Centre fosters close partnerships between our university- based researchers and industry-based research end-users to provide transformative

research programs and innovative doctoral training in FBD. The strategy of FBD involves screening libraries of small chemical compounds or 'fragments' that, owing to their size, generally bind with relatively low affinity and then elaborating these to produce larger, higher

affinity ligands (or hits). Projects may include; medicinal chemistry, structural biology, biophysics, and/or biochemistry.

The CFBD is supported by industry partners CSIRO, GE Healthcare Australia Pty Ltd, Mestrelab Research SL, Takeda California Inc., TetraGenetics Inc., VAST Bioscience Pty Ltd, Vernalis (R&D) Ltd, BioCurate Pty Ltd, FB Rice Pty Ltd, and Clarivate Analytics Ltd.

It is a condition of the scholarship that the successful applicant completes a 12-month placement with an ARC CFBD industry partner during and as part of their candidature.

The CFBD will develop and optimise innovative strategies for identifying novel ligands across a broad range of protein targets with clinical significance.

Project 1: Developing and optimising chemical elaboration (REFiL) of fragments into potent leads for Cancer/Metabolic disease (Scanlon lab)

Project 2: Developing and optimising chemical elaboration (REFiL) of fragments into potent leads as anti-infective compounds (Norton or Scanlon lab)

Project 3: Development of new approaches to expression of proteins to enable FBD for larger, more complex and membrane-bound proteins (Norton or Capuano lab)

Project 4: Developing and optimising chemical elaboration (REFiL) of fragments into potent leads for Type 2 diabetes (Norton and/or Baell lab)

Project 5: Optimising fragment screening methods (NMR) and fragment hit ranking strategies to identify compounds that bind to allosteric modulators of osteoporosis and asthma (Capuano and/or Scanlon lab)

Applications are invited from outstanding and enthusiastic graduates with relevant backgrounds (biophysics, biochemistry, chemistry).

Informal inquiries are strongly encouraged and should be directed to the Centre Manager, Dr Narelle Tunstall, cfbd@monash.edu.

To submit your application, please follow the ‘Apply Now’ button below.

Candidates are required to submit the following;

Please identify your project/s of interest within your cover letter.


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