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Postdoctoral Postdoc Position at University of North Carolina Chapel Hill

Applications are invited for a postdoctoral scholar position in developmental biology to join University of North Carolina Chapel Hill, USA. Applications will be evaluated on a continuous basis.

The Integrative Program for Biological & Genome Sciences (iBGS) operates at the interface between the UNC-CH School of Medicine and the College of Arts & Sciences to support research that works towards a mechanistic understanding of basic biological processes, thereby generating discoveries that fuel the translational research pipeline. iBGS is uniquely well situated to support and promote the integration of fundamental new discoveries with etiological and therapeutic efforts by clinician-scientists to combat human disease.

The laboratory of Dr. Bill Marzluff studies the regulation of histone mRNAs during the cell cycle, in both mammalian cells and in Drosophila. We are using CRISPR knock-out and knock-in approaches to study the specific role of factors required for histone pre-mRNA processing, translation and degradation. The ultimate goal is to reconstitute biochemical systems that reproduce these three major steps in histone gene expression. We are seeking a highly motivated candidate with PhD training in molecular, cellular, or developmental biology. This individual will perform research on the molecular mechanisms of and demonstrate expertise in molecular biology and biochemistry. The candidate could initiate a new project or contribute to ongoing projects such as: 1) Characterizing factors/complexes involved in histone mRNA translation and/or degradation using CRISPR/Cas9 genome editing of factors and regulatory sequences to functionally characterize these complexes in mammalian cells. 2) Biochemical studies of these factors in vitro to form functional complexes for biochemical studies in vitro. 3) characterization of complexes involved in histone pre-mRNA processing. This individual will display critical thinking and leadership skills as they guide research projects to publication. Application materials should include a CV, cover letter (with summary of research experiences, future interests and availability date), reprints of publications, and contact information for three references. The application materials should be uploaded on the UNC Human Resources website under this posting.

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