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PhD Scholarship Position in Nanomedicine at Chalmers University of Technology

Chalmers University of Technology, Sweden is inviting applicants to apply for a PhD position in medical sciences. The initial contract for this position is four years. Potential candidates should apply before July 31, 2019.

The Department of Biology and Biological Engineering was founded January 1 2015, and started off with high ambitions. The aim was to grow and become a leading center of innovation by combining the latest research in life sciences with biochemistry. And the department got off to flying start. In its first year, the numbers for publication, citation and external funding have been excellent.

The department consists of four divisions, each conducting outstanding research in the areas of industrial biotechnology, systems biology, chemical biology and food science. The overall goal is to help build a sustainable society and improve human health. Nearly 200 people from 20 countries are currently working at the department. The working environment is characterized by respect, cooperation, responsibility, creativity and job satisfaction. The Department of Biology and Biological Engineering has summarized its mission in four points: - To be an attractive environment for top-level researchers in biological engineering - To deliver top-level research results and innovative solutions for use in a sustainable society - To offer excellent education that develops creative engineers and scientists - To be a major contributor to international visibility of Chalmers Information about the research

A four-year PhD position in nanomedical research is available in a new junior group embedded in the Division of Chemical Biology and the Excellence Initiative Nano at Chalmers.

Disease-triggered drug-delivery vehicles can be composed of responsive polymeric materials that undergo programmed changes in their physicochemical properties (e.g. chain cleavage or solubility switch) upon exposure to the biochemistry of inflammation. To improve drug-delivery for these conditions, our group explores avenues such as reduced dosage, locally triggered on-time delivery, and functionality, or include diagnostics to monitor therapeutic response. We use established anti-inflammatory drugs and novel bioactive lipids for our purposes, and monitor drug effects in in vitro/ex vivo systems including tools such as lipidomics.

Major responsibilities

The successful candidate will work in a highly interdisciplinary project at the interface of polymer chemistry, materials science and cell biology. In this project, we aim to utilize interactions between nanoparticles and immune cells for diagnostic and therapeutic purposes of inflammatory disorders.

- Development and characterization (e.g., optical and electron microscopy, flow cytometry, DLS) of glycoprotein-targeting nanoparticles.

- Optimizing particle properties for the intended target.

- Ensuring controlled delivery of particles to targets and controlled release via suitable triggers (pH, etc.).

- Utilize immunological in vitro test conditions for a realistic simulation of in vivo conditions.

- Management, presentation and publication of research data.

Your major responsibilities are to pursue your own doctoral studies. You are expected to develop your own scientific concepts and communicate the results of your research verbally and in writing, both in Swedish and in English. The position generally also includes teaching on Chalmers’ undergraduate level or performing other duties corresponding to 20 percent of working hours.

Full-time temporary employment.The position is limited to a maximum of four years.

Qualifications

Candidates must hold (or be close to completion of) a Master of Science or equivalent degree in a relevant field (bio/nanotechnology, biomedical science, materials science, chemistry or pharmaceutical technology or similar). We are looking for a highly motivated and well-organized individual with good problem-solving skills and the ability to deliver high precision lab work. You should be able to work independently and develop your own project further. A master's project or previous work experience in biomaterials or drug delivery is considered a plus.

Experience within one or more of the following areas will also be an advantage:

- Chemical synsthesis and analysis methods (NMR, LC-MS)

- Microscopy techniques (SEM, TEM, optical microscopy).

- Cell culture

The position requires sound verbal and written communication skills in Swedish and English. If Swedish is not your native language, you should be able to teach in Swedish after two years. Chalmers offers Swedish courses.

Chalmers offers a cultivating and inspiring working environment in the dynamic city ofGothenburg.

Read more aboutworking at Chalmersand ourbenefitsfor employees.

Application procedure

The application should be marked with Ref 20190296 and written in English.

CV: (Please name the document: CV, Family name, Ref. number)

CV

Other, for example previous employments or leadership qualifications and positions of trust.

Two references that we can contact.

Personal letter: (Please name the document as: Personal letter, Family name, Ref. number)

1-3 pages where you introduce yourself and present your qualifications.

Previous research fields and main research results.

Future goals and research focus.Are there any specific projects and research issues you are primarily interested in?

Copies of bachelor and/or master's thesis.

Attested copies and transcripts of completed education, grades and other certificates, eg. TOEFL test results.

Application deadline: July31 2019

Alexandra Stubelius, Chemical Biology, astubelius@ucsd.edu

Fredrik Westerlund, Chemical Biology, fredrik.westerlund@chalmers.se


Summary:

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