PhD Scholarship in Vascular Biology at The University of Queensland

The University of Queensland, Australia has an opening PhD position in biochemistry. The initial contract for this position is three years. Applications are invited up to June 14, 2019.

The University of Queensland's Institute for Molecular Bioscience, located on the main University campus, is Australia's leading biosciences research institute. Established in 2000, the Institute is home to over 420 staff and is located in thriving Brisbane, a city consistently ranked as one of the world's most vibrant and liveable cities.

Details of the research interests of the Institute may be accessed at:

Blood vessels form complex branched networks comprised of arteries, capillaries and veins that supply oxygen and nutrients to all body tissues. Vascular outgrowth occurs through a process called sprouting angiogenesis, which is essential for laying down a functional vessel network during embryonic development. Abnormal angiogenesis is also a key factor during diseases such as cancer, diabetes and stroke. The broad aim of our lab is to investigate the molecular mechanisms behind blood vessel growth and function during development and disease.

We are seeking a dynamic, intelligent, highly motivated PhD student to work on a project that will be further developed with input from the successful applicant.

AIM 1: To define the mechanisms regulating pathological vessel growth in the eye. Using the model of Oxygen Induced Retinopathy, this project will define the proteins that regulate vascular growth and function in a disease model. This will help to identify new targets to prevent pathological vessels from forming, while leaving healthy vessels unaffected.

AIM 2: Understanding distinct how vessels sprout from different sources.Using knockout models and novel cull culture techniques, this project will investigate the mechanisms that regulate the loosening of cell adhesions in distinct vessel systems. This project is built on the preliminary findings that temporal and spatial regulation of protein activity can be a fine-tuning factor that is required to regulate cell dynamics during vessel sprouting, which allows for differentiated networks to form with distinctive cell adhesiveness.

AIM 3: Investigating dynamics of cell-cell and cell-matrix adhesion. In order for vessels to sprout, cells in the blood vessel wall need to be able to form contacts with their neighbours and with their surrounding environment. Using cutting edge microscopy techniques and in vivo models, this project will investigate the mechanisms behind these adhesion processes in growing vessels

Both Australian and international applicants are welcome to apply. The successful candidate should have a First Class Honours Degree or Masters Degree (or equivalent), majoring in vascular biology, cell biology and/or biochemistry or a related discipline.

You should also have a strong desire to develop a successful and highly-productive research career in the biological sciences, good general research skills, a strong methodological background, excellent statistical and analytic skills, very good writing abilities, and the capacity to work with multidisciplinary research teams.

The University of Queensland values diversity and inclusion and actively encourages applications from those who bring diversity to the University. Please refer to the University's Diversity and Inclusion webpagefor further information and points of contact if you require additional support. Accessibility requirements and/or adjustments can be directed to the contact person listed below.

To be eligible to apply, you must also meet the entry requirements for Higher Degrees by Research at UQ. Please visit theGraduate School’s website.

The 2019 Research Training Program (RTP) living allowance stipend rate is AUD$27,596 per annum (indexed annually), which is tax-free for three years with two possible extensions of up to 6 months each in approved circumstances (conditions apply). For further information on this scholarship refer to:

For further information, please contactDr Emma Gordon.

Please visit the advertisement on the Grad School websitefor information on how to apply.Please donot click the apply button below.


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