PhD Scholarship in Medical Science The Renal Injury Response and Regeneration

University of Gothenburg is pleased to invite applicants to apply for a new opening PhD position in medical sciences. Successful candidate will have funding to work and study for four years in Sweden. This position is closed on June 18, 2019.

Doctoral student in Medical Science – The renal injury response and regeneration

Third-cycle studies are equivalent to four year full-time and lead to a Degree of Doctor. Those appointed to doctoral studentships shall primarily devote themselves to their studies. Those appointed to doctoral studentships may, however, work to a limited extent with educational tasks, research and administration. Before a PhD degree has been awarded,duties of this kind may not comprise more than 20 per cent of a full-time post.

The PhD educationin Medical Science comprisecarrying out a scientific project and completing at least 30 credits of courses at third-cycle level. The doctoral student must also write a scientific compilation thesis or monograph corresponding to at least 120 credits. For more information about third-cycle studies at Sahlgrenska Academy, see


Background:Kidney disease is globally reaching almost epidemic proportions with enormous costs both in patient suffering and in economic terms. In the US, the current prevalence of chronic kidney disease is approximately 14% of the population. Manifest kidney disease is the consequence of an imbalance between injury and the reparative capacity of the kidney. Despite their importance, the mechanisms governing kidney regeneration are far from elucidated. Parts of the kidney cells are very sensitive to reduced oxygen tension and nutrient deprivation. The classical injury theory holds that stochastically surviving cells drive regeneration. A more recent concept is that kidney stem or progenitor cells perform kidney repair. We have previously identified and characterized a tubular scattered cell population in the proximal tubules of the human kidney with progenitor-like characteristics.

Aim:This Ph.D project aims at continuing the investigation of the renal response to injury and ensuing reparative functions. A primary target is to establish if this capacity is driven by stem cells or not. Furthermore it is of central importance to isolate the regenerative cells for further study. Ultimately we strive to understand how the renal regeneration is controlled in order to enable pharmacological treatment of acute and chronic kidney disease.

Work plan:We isolate and culture primary human tubular cells in vitro, including 3D culturing. Standard cell and molecular biological techniques are used, such as Western blotting, Q-PCR, Immunohistochemistry, confocal microscopy, RNA/DNA extraction etc. We also use RNA seq and bio informatics. In cooperation with the Lund Technical University we have designed a micro fluidics chip in order to study tubular cells during flow conditions. We also cooperate with the University of Nottingham to establish a kidney injury model in experimental animals. Finally we use flow sorting of cells suspensions to enrich for the regenerative cells.The laboratory is situated at Gteborg University, where a center for advanced kidney research has recently been established. During cooperations laboratories in Malm and Lund will be also be used. To be eligible for third-cycle studies, the applicant must meet both the general and specific entry requirements.

for third-cycle studiesif he or she:

1. has been awarded a second-cycle qualification 2. has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle, or 3. has acquired substantially equivalent knowledge in some other way in Sweden or abroad for third-cycle studiesin Medical Science if he or she: has successfully completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies

In selecting between applicants who meet the general and specific entry requirements, their ability to benefit from third-cycle studies shall be taken into account. The assessment shall attach particular importance to documented qualifications for:

– specific knowledge and skills within the subject area and related research fields – experience of scientific theory and relevant research methodology – scientific analysis and presentation verified through thesis, degree project, scientific journals or the like. After admission tothird-cyclestudies you will be appointedtodoctoral studentship. Regulations for employment of doctoral students are given in SFS 1993:100. The initial appointment may apply for no longer than one year. An appointment may be renewed for no more than two years at a time. A person may beappointed to a doctoral studentship for a total ofeight years. The total employment period may, however, not exceed the time corresponding to full-time third-cycle study for four years.

Location: Sahlgrenska Academy, Institute of Biomedicine, Department of Laboratory Medicine.

Extent:100%. First day of employment: as agreed. Salaries for doctoral students are regulated in a local agreement at the University.

For more information about the project please contact the principal supervisor,

Martin Johansson,Professor, Institute of Biomedicine, e-mail: Union representatives at the University of Gothenburg:

In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline.

You must include the following, in pdf format

If your degree is from a university outside of Sweden, check what you need to submit at where you can also see what you need to submit in order to fulfill the English language requirement.

The University of Gothenburg promotes equal opportunities, equality and diversity.

Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.


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