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Research Assistant at University of Cambridge

Applicants are invited to apply for a postdoctoral researcher position in molecular biology at University of Cambridge. The deadline for applying is March 10, 2019.

Applications are invited for a Research Assistant to join the team of Dr Emmanouil Metzakopian, in the newly established UK Dementia Research Institute (UK DRI) Centre at the University of Cambridge, Cambridge Biomedical Campus, Cambridge UK to work on CRISPR screening and single cell analysis of iPSC-derived neurons.

The mission of the UK DRI at the University of Cambridge, is to create a collaborative, inter-disciplinary Centre, combining world-leading expertise unique to Cambridge from chemistry, biophysics and structural biology with internationally leading research in the cell biology of neurodegeneration. This environment will enable creative and innovative approaches to the study of neurodegenerative disease and drive a gear change in our scientific understanding.

The scientific focus of the Centre is on understanding mechanisms involved in the earliest stages of neurodegenerative disease in order, ultimately, to deliver therapeutic targets with the greatest potential to prevent dementia. Three Foundation programmes led by DRI professors are complemented by three new programmes led by DRI Fellows (including Dr. Metzakopian) to develop this field.

We are now looking for a Research Assistant to join the laboratory of Dr. Emmanouil Metzakopian. The focus of the Metzakopian lab is on insights into novel neuroprotective mechanisms in neurodegeneration that provide new targets for treatments of these disorders.

The project is funded by Open Targets, as a joint venture between Dr. Metzakopian at the UK DRI and Open Targets partners including the Wellcome Sanger Institute, the European Bioinformatics Institute, GSK, Biogen, Takeda, Cellgene and Sanofi. The aim is to identify and validate therapeutic targets for neurodevelopmental and psychiatric disorders with a known genetic basis, by comparing molecular profiles of disease states to the response profiles of drugs and gene knockouts using CRISPR-Cas9. This study leverages substantial genetic and functional resources within Open Targets.

Education to graduate level in a relevant subject is required. Knowledge of techniques in cell and molecular biology is essential although training in all relevant techniques will be provided.

To learn more about Open Targets please visit: www.opentargets.org

For further enquiries please contact: em698@medschl.cam.ac.uk

Fixed-term: The funds for this post are available until 1 January 2022 in the first instance.

Please ensure that you upload your Curriculum Vitae (CV) and a covering letter in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including e-mail address and phone number, one of which must be your most recent line manager


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