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PhD Scholarship in Cell and Molecular Biology at University of Gothenburg

University of Gothenburg is delighted to offer a PhD position in medicinal chemistry. This position is available for 5 years. This position is closed on March 04, 2019.

Research and graduate education at the department of chemistry and molecular biology comprises a wide scientific field from the atomic and molecular levels all the way through cells to intact organisms. Much of the phenomena studied here impact on our natural environment and living systems. We participate in undergraduate programs in chemistry, molecular biology, medicinal chemistry, biology, marine sciences, and pharmacy.

A third cycle education at our department will lead to a Ph.D. in Natural sciences, or Natural sciences with a specialisation in Chemistry, Biology or Biophysics. Ph.D. studies comprises four years at the post graduate level. The time period can be extended to 5 years in total through teaching and/or other departmental duties.

Our research is focused on understanding the interplay between the cytoskeleton and the molecular chaperone CCT, with particular focus upon the remodelling of the cytoskeleton, cell migration and invasion. Both actin and tubulin (components of the cytoskeleton) require interactions with the CCT oligomer to be correctly folded. Some CCT subunits also have additional functions connected to the cytoskeleton, for example CCTd interacts with a component of the dynactin complex. We use a combination protein biochemistry and cell biology methods and also use the Centre for Cellular Imaging for microscopy work. Our long term goal is to understand the processes involved in cancer cell migration and identify potential targets for new cancer therapies.

As a PhD student in the project you will be involved in using cultured mammalian cells and pure protein systems to study the interplay between the cytoskeleton and the molecular chaperone CCT.

1) Protein:protein interaction studies using immunoprecipitation and pull down assays of transfected and endogenous proteins. Protein purification for in vitro assays.

2) Protein depletion studies using siRNA followed by functional assays

3) Cell imaging. This will use a variety of techniques including wide-field, confocal and super-resolution fluorescence microscopy and live cell imaging.

You will be expected to develop current protocols to develop live cell imaging in both a 2 and 3 dimensional environment.

1. has been awarded a second-cycle qualification, 2. has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle, or 3. has acquired substantially equivalent knowledge in some other way in Sweden or abroad. To meet the specific entry requirements for third-cycle studies, applicants must: (i) have a second-cycle (advanced-level) degree in a relevant* subject area in the natural sciences, or (ii) have completed studies for at least 60 higher education credits at a second-cycle level in relevant subject areas in the natural sciences, or (iii) have completed a corresponding programme of relevance to the planned third-cycle programme, in Sweden or in another country, or have equivalent qualifications. The specific entry requirements also include an acceptable command of spoken and written English. Guidelines for assessing English proficiency may include a minimum score of 550 on the TOEFL test (or 213 on the TOEFL-CBT, or 79 on the TOEFL-iBT).

Regulations for the evaluation of qualifications for education on a doctoral level are given in SFS 1998:80.

Type of employment: Fixed-term employment, Four years full time

Extent: 100 % Location: Department of Chemistry and Molecular Biology, Gothenburg First day of employment: as agreed upon Regulations for the evaluation of qualifications for education on a doctoral level are given in SFS 1998:80.

A new employment as a PhD student applies for a maximum of one year. The Appointment may be prolonged for up to two years at a time. The total employment period may not be longer than the equivalent of four years of full time time doctoral studies.

Cover letter with an explanation of why you apply for the position

CV including scientific publications Copy of exam certificate Two references (name, telephone no, relation) Julie Grantham, Associate Professor julie.grantham@cmb.gu.se

Questions regarding the third-cycle education: Martin Billeter, Director of third cycle education, +46(0) 31-786 3925, martin.billeter@gu.se Questions regarding the employment: hr@cmb.gu.se Union representatives at the University of Gothenburg: http://www.gu.se/english/about_the_university/job-opportunities/union-representatives

In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline. The selection of candidates is made on the basis of the qualifications registered in the application.


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