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PhD Scholarship in Regenerative Neurobiology at Monash University

Applicants are invited to apply for a PhD position in genetics at Monash University, Australia. The funding allows successful candidate to work for 6 months. Applications are welcome before February 18, 2019.

Remuneration:Annual living allowance based on Monash University's Research Training Program (RTP), stipend of $27,872 per annum (2019 rate – indexed annually), plus a top-up living allowance of $5,000 per year

A PhD position is being offered to join the Merson group at the Australian Regenerative Medicine Institute (ARMI) to examine how age-related epigenetic changes in neural stem and progenitor cells influence their capacity to remyelinate the brain. The Merson group studies the cellular and molecular interactions between neurons and myelin-forming oligodendrocytes in the central nervous system. A major goal of the group's research is to develop strategies to promote myelin repair in diseases such as multiple sclerosis. Merson Lab website: https://www.mersonlab.org/.

Myelin regeneration is critical for preventing axonal loss in patients with multiple sclerosis and in animal models of demyelination. DrMerson's group has demonstrated that both oligodendrocyte progenitor cells (OPCs) and neural stem/progenitor cells (NSPCs) can regenerate myelin in young mice and that the myelin regenerated by NSPCs is superior to that produced by OPCs. Ageing reduces the regenerative capacity of both OPCs and NSPCs. Whilst age-related epigenetic modifications in OPCs have been shown to reduce their regenerative capacity, this has not been explored for NSPCs. This project will compare the epigenetic changes in NSPCs and OPCs during ageing and adopt partial in vivo reprogramming to restore youthful chromatin structures in these populations to enhance remyelination in aged mice.

The PhD scholarship is being offered as part of the newly-established Monash University and The Chinese University of Hong Kong (CUHK) PhD exchange programme. The programme aims to provide our PhD students with opportunities to access research expertise, resources and infrastructure at both institutions. The PhD candidate will be based at ARMI and conduct the majority of their research at Monash University. The candidate will also have the opportunity to spend up to 6 months at The Chinese University of Hong Kong (CUHK) under the co-supervision of Assistant Prof. Cynthia Jiang. A travel allowance of $5,000 to contribute to costs associated with the candidates travel to and from CUHK will be provided.

Applicants will be considered provided that they fulfil the criteria for PhD admission at Monash University. Details of eligibility requirements to undertake a PhD at ARMI are available athttp://www.armi.org.au/careers-education/higher-degree-research.

Candidates will be required to meet Monash entry requirements which include English-language skills.

Successful applicants will be expected to enrol no later than1st April 2019.

Submit your expression of interest to DrTobias Merson (tobias. merson@monash.


Summary:

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