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Open Position for A PhD Scholarship Within The Collaborative Research Centre

Technical University of Munich is pleased to invite applicants to apply for a new opening PhD position in molecular biology. This position is available for 4 years. This position is open until filled.

The gut microbiome plays a fundamental role in health and disease. CRC 1371 (Speaker Prof. Dr. Dirk Haller) focuses on the digestive tract and proposes an interdisciplinary approach to characterizing the functional relevance of microbiome signatures in the context of inflammation and cancer. Within CRC 1371, the Integrated Research Training Group (IRTG) provides a qualification program for PhD students containing excellent multidisciplinary training with tailor-made subject-based and soft skills courses, annual retreats, summer school, and a supervision concept.

Job description "Impact of dietary fat-gut microbiota interaction on intestinal lipid absorption, systemic lipid metabolism and intestinal cancer" Variation in dietary fat and gut microbiota affect intestinal lipid resorption, systemic lipid metabolism and energy balance. Excess dietary fat intake promotes positive energy balance, fat accretion and obesity, which is a significant risk factor for colorectal cancer. The aim of this project is to reveal the role of dietary fat - microbiota interaction on host lipid metabolism under physiological and patho-physiological conditions. Wildtype and Apc1638N germ-free (GF), Oligo-MM and specific pathogen-free (SPF) receiving different diets will be tested for differences in lipid metabolic processes. The effects of microbiota and dietary fat on energy balance will be assessed in mouse models. This includes calorimetric methods to measure energy intake, energy excretion and intestinal absorption efficiency, but also energy expenditure and metabolic fuel selection. To gain mechanistic insights, untargeted and targeted lipidomics will be applied to identify bioactive lipids (microbiota-, diet- and host-derived) and test their functional relevance. Taken together, the aim of the project is to define diets and gut microbiota communities beneficial in the suppression of obesity-driven metabolic diseases and intestinal cancer. Related publication: Kbeck R, et al. Dietary fat and gut microbiota interactions determine diet-induced obesity in mice. Mol Metab. 2016 Oct 13;5(12):1162-1174. Techniques/methods to be applied include: - In vivo mouse experiments - Metabolic phenotyping of mouse models - Mass spectrometry/Lipidomics (GC-MS) - Molecular biology and biochemistry - Cell culture Required qualification Candidates hold a Master degree (or equivalent) in biology, biochemistry or nutritional sciences (or equivalent). They are open minded, active and have a good command of the English language (oral and written). Salary and duration Payment is according to the wage agreement of the civil service TV-L, 65% of E13 for PhD student positions for 4 years. Application deadline Applications will be considered until the position is filled. Contact person Prof. Dr. Martin Klingenspor Technical University of Munich (TUM) Chair for Molecular Nutritional Medicine Gregor-Mendel-Str. 2 85354 Freising Germany E-mail: mk@tum.de Application Applicants are asked to send one pdf file to the contact person. The file includes 1. cover letter, 2. curriculum vitae, 3. copies of academic degrees and transcripts of records, 4. contact information for at least one letter of recommendation, 5. list of publications (if existing). As an equal opportunity and affirmative action employer, TUM explicitly encourages applications from women as well as from all others who would bring additional diversity dimensions to the university's research and teaching strategies. Preference will be given to disabled candidates with essentially the same qualifications.

Summary:

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