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PhD Scholarship in Diet Gut Microbiota

Technical University of Munich is offering PhD position in biochemistry. The initial contract for this position is 4 years. Applicants should apply as soon as possible.

ZIEL – Institute for Food & Health (TUM), Freising-Weihenstephan, Germany Group "Lipid Metabolism", Josef Ecker offers an open PhD position in "Diet – gut microbiota – lipid metabolism – intestinal cancer"

The gut microbiome plays a fundamental role in health and disease. CRC 1371 (Speaker Prof. Dr. Dirk Haller) focuses on the digestive tract and proposes an interdisciplinary approach to characterizing the functional relevance of microbiome signatures in the context of inflammation and cancer.

Variation in dietary fat and gut microbiota affect intestinal lipid resorption, systemic lipid metabolism and energy balance. Excess dietary fat intake promotes positive energy balance, fat accretion and obesity, which is a significant risk factor for colorectal cancer. The aim of this project is to reveal the role of dietary fat - microbiota interaction on host lipid metabolism under physiological and patho-physiological conditions. Wildtype and Apc1638N germ-free (GF), Oligo-MM and specific pathogen-free (SPF) receiving different diets will be tested for differences in lipid metabolic processes.

Intestinal lipid absorption and systemic lipid metabolism will be investigated by application of stable isotope labeled tracers (non-radioactive) in combination with mass spectrometric analysis. To gain mechanistic insights, bioactive lipids (microbiota-, diet- and host-derived) will be identified and tested for functional relevance. Together, the aim of the project is to define diets and gut microbiota communities beneficial in the suppression of obesity-driven metabolic diseases and intestinal cancer.

Related publication: Kindt et al., (2018), The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice, Nature Communications, 9(1):3760, DOI: 10.1038/s41467-018-05767-4)

Required qualification

Candidates hold a Master degree (or equivalent) in biology, biochemistry or nutritional sciences (or equivalent). They are open minded, active and have a good command of the English language (oral and written).

Salary and duration

Payment is according to the wage agreement of the civil service TV-L, 65% of E13 for PhD student positions for 4 years.

Contact person

Dr. Josef Ecker

Technical University of Munich (TUM) ZIEL - Institute for Food & Health Gregor-Mendel-Str. 2 85354 Freising Germany As an equal opportunity and affirmative action employer, TUM explicitly encourages applications from women as well as from all others who would bring additional diversity dimensions to the university's research and teaching strategies. Preference will be given to disabled candidates with essentially the same qualifications.

Summary:

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