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Postdoc in Enzymology at Technical University of Denmark

Technical University of Denmark is offering postdoctoral researcher position in applied mathematics. All candidates regardless of citizenship are eligible to apply before January 20, 2019.

A Postdoc position is available at theSection for Protein Chemistry & Enzyme Technology. Research in this sectionaims to attain new knowledge within protein- and enzyme-structure function relations, enzyme-substrate interactions, biocatalytic mechanisms, energy relations and kinetics, and on enzyme-protein robustness and stability.

The research will be conducted in the headed by prof. Peter Westh. The group investigates enzyme reactions that occur at the interface of two immiscible phases; examples include the modification of insoluble substrate and activity of immobilized enzymes. We strive to provide rigorous kinetic descriptions of such processes and to use kinetic and structural knowledge in rational design of improved enzymes for industrial applications.

The main theme of the work will be rational enzyme design. This will involve thorough kinetic characterization of enzyme activity on insoluble substrate as well as analysis and mathematical modelling of the results. The project has special focus on relationships between substrate binding strength and catalytic efficacy, and this includes analysis of so-called Linear Free Energy Relationships and application of the Sabatier Principle. Some relevant models for the analysis of kinetic data have already been developed within the Interfacial Enzymology group, but adaptions as well as implementation of novel model approaches may also be a part of the work. The work will be conducted in close collaboration with experimentalists and computational scientists at DTU Bioengineering and DTU Chemistry. As a postdoc, you will take part in the supervision of PhD students associated with the project, and you will be committed to the integration of the project's experimental and computational activities. The project also involves close collaboration with protein chemists and molecular biologists from Novozymes A/S and applied mathematicians from Roskilde University.

All interested candidates irrespective of age, gender,disability, race, religion or ethnic background are encouraged to apply.

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