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PhD Studentship at University of Cambridge

University of Cambridge, UK is offering PhD position in biochemistry. The funds for this fellowship are available for 4 years. Applications should be sent before January 11, 2019.

A fully funded 4-year PhD studentship is available, as a BBSRC Collaborative Training Partnership (CTP) between Eli Lilly and the University of Cambridge, commencing October 2019, with a project titled “Microglial phagocytosis in brain ageing”.

During ageing and neurodegeneration of both mice and humans, the brain loses synapses and the ability to learn and remember. Microglia are brain macrophages that eat (phagocytose) synapses and neurons in specific circumstances. Prof. Brown’s lab have shown that a particular microglial receptor mediates phagocytosis of synapses, and that knockout of this receptor prevents neurodegeneration- and age-induced memory loss. This project examines the relevant signalling between neurons and microglia, and the role of microglial phagocytosis in age-induced lose of synapses and memory in mice, using cell culture, mice, imaging and molecular cell biology.

Reference: Vilalta A, Brown GC (2018) Neurophagy, the phagocytosis of live neurons and synapses by glia, contributes to brain development and disease. FEBS J. 285:3566-3575.

The aim of the BBSRC CTP awards is to provide PhD students with a challenging research training experience within the context of a mutually beneficial research collaboration, between academic and industrial partner organisations. The student will based in the laboratory of Prof. Guy Brown in the Department of Biochemistry, University of Cambridge, and will be jointly supervised by scientists at Eli Lilly in Surrey.

Applicants should hold a First class degree in a relevant subject (Neuroscience /Molecular Cell Biology/Biochemistry), as well as research experience. BBSRC studentships are available to UK nationals and EU students who meet the UK residency requirements. Further information about eligibility for Research Council UK funding can be found on the BBSRC website: http://www.bbsrc.ac.uk/documents/studentship-eligibility-pdf/ The successful candidate will receive a stipend paid at RCUK rates for the 4 year duration of the award (14,999 per annum for 2019-2020); fees will be met in full for UK nationals or EU nationals meeting BBSRC residency requirements.

Fixed-term: The funds for this post are available for 4 years.

Applications should be sent to Prof. Guy Brown (gcb3@cam.ac.uk) by 11th January 2019, enclosing a cover letter, a detailed curriculum vitae and the names and contact details of two academic referees.

Enquiries about the online application process can be sent to the departmental HR team at personnel@bioc.cam.ac.uk.


Summary:

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