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PhD Position in Medical Science Adiponectin and Rheumatoid Arthritis

A fully-funded PhD fellowship in molecular biology is available at University of Gothenburg. The initial contract for this position is 4 years. The deadline to apply is January 28, 2019.

At the department of Rheumatology and Inflammation Research, Inflammation is the main topic of the research conducted within the department. Our research groups perform studies of inflammatory diseases, whether caused by allergy, infection, or autoimmune disease. The goal is to investigate the mechanisms underlying the body’s tissues become inflamed.Many of our researchers are also working as a specialist physician at the clinic at Sahlgrenska University Hospital, which is also one of our greatest assets.

The Wallenberg Centre for Molecular and Translational Medicine in Gothenburg is a new center at the University of Gothenburg (https://wcmtm.gu.se/). The center consists of different research groups, focusing on diverse topics ranging from neuroscience to metabolism and diabetes.In the frame of the Wallenberg Centre, Maglio group studies the interaction between obesity and the development of rheumatic diseases.

Project title: Role of adiponectin in the development of rheumatoid arthritis

General information about third-cycle studies: The PhD education in Medical Science corresponds to studies of 240 credits in total. The studies are equivalent to four year full-time and lead to a Degree of Doctor. The studies comprisecarrying out a scientific project and completing at least 30 credits of courses at third-cycle level. The doctoral student must also write a scientific compilation thesis or monograph corresponding to at least 120 credits. For more information about third-cycle studies at Sahlgrenska Academy, see

Project: The aim of this research project is to understand the role of adiponectin in the pathogenesis of rheumatoid arthritis. Rheumatoid arthritis is a chronic invalidating autoimmune disease affecting about 1% of the Swedish population. Subjects with rheumatoid arthritis have elevated levels of adiponectin in both serum and joint fluids. Adiponectin is a cytokine produced by the adipose tissue (i.e. an adipokine), mostly known to have anti-inflammatory properties and to be associated with a favourable metabolic profile. However, recent studies show that adiponectin also has pro-inflammatory effects in different cell types. We hypothesize that adiponectin plays a role in the development of rheumatoid arthritis. We will test this hypothesis by using a wide range of methods and technologies in the field of molecular biology, immunology and genetics. The project will involve independent work in the laboratory using in vitro cell models, analysis of data from big patients' cohorts, as well as collaboration with clinicians, epidemiologists and other research groups.

We are seeking an enthusiastic applicant to be part of ourteam of researchers at the Department of Rheumatology and Inflammation Research.The successful applicant will be actively involved in the work of the research team whose aim is to provide new understanding about the pathogenesis of rheumatoid arthritis, a common, invalidating inflammatory disease. The PhD student will have the opportunity to present the results of the project at national and international conferences, and will be provided with comprehensive mentoring and support for further career development. To be eligible for third-cycle studies, the applicant must meet both the general and specific entry requirements.

A person meets the general entry requirements for third-cycle studiesif he or she:

1. has been awarded a second-cycle qualification 2. has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle, or 3. has acquired substantially equivalent knowledge in some other way in Sweden or abroad A person meets thespecific entry requirements for third-cycle studiesif he or she: has successfully completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies

In selecting between applicants who meet the general and specific entry requirements, their ability to benefit from third-cycle studies shall be taken into account. The assessment shall attach particular importance to documented qualifications for:

– specific knowledge and skills within the subject area and related research fields – experience of scientific theory and relevant research methodology – scientific analysis and presentation verified through thesis, degree project, scientific journals or the like. Documented experiencein laboratory work as well as in data analysis and use of common statistics software (e.g. SPSS, SAS, R) isof value.Good communication skillsis desirable.Great emphasis will be placed on personal suitability.

Time limited employment (temporary),4 years.Extent:100%. Location: Sahlgrenska Academy, Institute of Medicine, Department of Rheumatology and Inflammation Research. First day of employment: as agreed.

Regulations for employment of doctoral students are given in SFS 1998:80.Only those who are admitted to third-cycle studies may be appointed to doctoral studentships. Those appointed to doctoral studentships shall primarily devote themselves to their studies. They may, however, work to a limited extent with educational tasks, research and administration according to the regulations.

The initial appointment may apply for no longer than one year. An appointment may be renewed for no more than two years at a time. The total employment period may not exceed the time corresponding to full-time third-cycle studies for four years.

Salaries for doctoral students are regulated in a local agreement at the University.

For more information about the project please contact the project supervisorCristina Maglio,

Phone +46 733 231 485, cristina.maglio@gu.se

In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. Attach verified copies of your education and English proficiency proving your eligibility in pdf format. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline. The selection of candidates is made on the basis of the qualifications registered in the application.

The University of Gothenburg promotes equal opportunities, equality and diversity.

Salaries for doctoral students are regulated in a local agreement at the University.

Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.


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