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Postdoc Position in Reconstituting Cdc42 Based Polarity in Vitro

Delft University of Technology has an opening postdoc position in biochemistry. This position is available for 2 years. Applications will be evaluated on a continuous basis.

Department/faculty: Faculty Applied Sciences

Level: Doctorate Working hours: 38.0 hours weekly Contract: 2 years Salary: to be agreed upon The Faculty of Applied Sciences is the largest faculty of TU Delft, with around 550 scientists, a support staff of 250 and 1,800 students. The faculty conducts fundamental, application-oriented research and offers scientific education at the bachelor, master and doctoral levels. The faculty is active in the fields of Life and Health Science & Technology, Nanoscience, Chemical Engineering, Radiation Science & Technology, and Applied Physics.

The Department of Bionanoscience (www.bn.tudelft.nl), part of the Faculty of Applied Sciencesand part of the Kavli Institute of Nanoscience Delft (www.kavli.nl), is dedicated to pioneering, fundamental research at the interface between physics and biology. This young, international department was established in 2010 and has since expanded to currently 19 faculty members. The department offers excellent general facilities, including a central optical microscopy facility, a cryo-EM facility, extensive general cell biology and biochemistry facilities, and a large cleanroom facility, the Kavli Nanolab Delft. The Department strives for a collegial, nourishing, and inclusive environment.

How cells establish polarity is one of the big open questions in cell biology, and a model for self-organization of protein networks. Most (quantitative) cell biological studies agree about the proteins involved, however they strongly disagree about how the interactions between these proteins lead to polarity establishment.

As part of a small team you will set up a minimal in vitro system for polarity establishment, which consists of the minimal set of proteins which reconstitute localisation and activation of a polarity protein (Cdc42) to a single site on an internal membrane of an artificial compartment (a liposome). With this system, combined with quantitative fluorescence microscopy you will (1) achieve a mechanistic understanding of the role of different key components for polarization, (2) characterize if, and if so how, the interactions of those components lead to the formation of a single site of activated Cdc42 on an artificial liposome membrane, (3) combine your mechanistic insights from in vitro experiments with mathematical modelling to describe polarity establishment in vivo.

Applicants should have a PhD degree in (bio)physics, (bio)chemistry, quantitative biology, or a related field, and enthusiasm for applying quantitative approaches to understanding biological phenomena and for performing challenging biophysical in vitro experiments. The position will be for two years. Good communication skills in English are required.

TU Delft offers a customisable compensation package, a discount for health insurance and sport memberships, and a monthly work costs contribution. Flexible work schedules can be arranged. An International Children's Centre offers childcare and an international primary school. Dual Career Services offers support to accompanying partners. Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities.

For more information about this position, please contact Liedewij Laan, phone: +31 (0)15-2782856, e-mail: L.Laan@tudelft.nl. To apply, please e-mail a detailed CV and list of references along with a letter of application, with a clear description of what attracts you to this particular position by December 15th 2018 to Ms. Nadine Kuijvenhoven(secretary), e-mail:N.Kuijvenhoven@tudelft.nl. When applying for this position, please refer to vacancy number TNWBN18-079.


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