Postdoc Position in Chemical Biology at Imperial College London

Applications are invited for a postdoctoral associate position in biochemistry to join Imperial College London, UK. The funds for this fellowship are available for 4 years. Applications are welcome before December 05, 2018.

Up to two Research Associate positions in chemical biology are available within the Chemistry Department at Imperial College, London, to work in the newly established Walport laboratory ( at the Francis Crick Institute.

The Walport lab is a highly interdisciplinary lab that uses a wide variety of techniques, spanning from synthetic and peptide chemistry to cell biology, to study proteins involved in the regulation of post-translational modifications. Our location in the Francis Crick Institute affords us access to a wealth of state-of-the-art technologies and expertise through the Scientific Technology Platforms alongside the stimulating environment provided by both the Crick and the Imperial College Chemistry Department. We are seeking motivated and enthusiastic chemical biologists to carry out novel research employing an mRNA-display-based peptide discovery platform, the RaPID system, to discover tools to better understand protein citrullination. The candidates will develop activity-based selection protocols to identify new chemical modulators of the peptidyl arginine deiminases; enzymes with key roles in inflammatory diseases and various cancers. The project will involve developing and optimising new peptide selection schemes to identify candidate peptides; biophysical and structural characterisation of identified peptides; lead peptide optimisation; and peptide characterisation and testing in cells. The project will be multidisciplinary, involving synthetic and peptide chemistry, biophysical characterisation of peptide hits, structural and cell biology. We are therefore seeking candidates with experience in a selection of these techniques and a willingness to learn others as dictated by the project. Experience with the development, optimisation and testing of peptide inhibitors or other chemical probes would be desirable.

- A PhD degree (or an equivalent level of professional qualifications) in a relevant field (e.g. chemistry, chemical biology, biochemistry) - Strong background in chemical biology - Extensive practical experience working on a multi-disciplinary project - A proven publication track record appropriate to their career path - Ability to work independently and within a team - Eagerness to learn new techniques This is a full time, fixed term position of 4 years.


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