Postdoc Position at Imperial College London

Applications are invited for a postdoc position in medical sciences to join Imperial College London, UK. The initial contract for this position is 18 months. The deadline for applying is December 05, 2018.

This is an exciting role in the development of a new fluorescence probe for protective macrophages and hemorrhage.

Apply for this unique post if you want a fascinating project that seamlessly blends chemistry and biology and want to make a genuine difference to the repertoire of biological and medical optical probes. Vascular Sciences are located in British Heart Foundation-funded floor in the recently opened Imperial College Translational and Experimental Medicine building, which opened in 2012 as dedicated state-of-the-art laboratories that connect medical science with Hammersmith Hospital. The Chemistry Department at Imperial College has just moved into state-of-the-art laboratories (Molecular Sciences Research Hub) co-located in the same overall campus as Hammersmith Campus. You will be responsible for carrying out enzyme assays and fluorescence assays for fluorescent chemical probes of Heme Oxygenase 1, and then discussing results with Dr Boyle and the chemistry team on the same project. This will involve close liaison between the post-holder, Dr Boyle, the recently-appointed chemistry post-doc and Prof Nick Long. Chemical fluorescence probes for specific biochemical measurements are increasingly popular. This will be the first such probe for heme oxygenase, a major anti-oxidant enzyme. This is therefore an ideal opportunity for a chemical biology project such as this postdoctoral research assistantship in fluorescence reporter probes for heme oxygenase 1 (HO-1). You will validate fluorescence probes for heme oxygenase 1 at the level of purified enzyme, cell and tissue. The fluorescence probes will have basic fluorescence characteristics measured, and compared with standard heme oxygenase activity assays in enzyme kinetics. You will liaise closely and constructively with the chemists on the project (Ed Walter and Nick Long) and with Joe Boyle. You will carry out data analysis of the probes. This will help build up a validation, and selection of the best probes, in increasingly complex systems. You will understand the probe mechanism and contribute to design discussions. You will spend most of your time on this project. You will also contribute some time more broadly to the wider unit (Vascular Sciences).

A keen interest in the project is essential. A willingness to learn is essential. The ability to be flexible is essential. The ability to interact effectively with scientists in a related discipline is essential. Strong communication is required. Some knowledge of the area is essential. Background in a related area is helpful. Basic data skills are essential. A commitment to data quality is essential. Experience in advanced image or fluorescence data analysis is helpful. An understanding of the process and importance of publishing is essential. In practice, this requires publication in refereed journals. A positive and flexible approach to interesting challenges will be required.

18 months fixed term duration, of which the first 12 months overlap with the post-doc chemist in a mirroring post. The start-date of the post is also fixed, early March 2019.


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