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Postdoc Position at Imperial College London

A new postdoctoral scholar position in molecular biology is available at Imperial College London. Potential candidates should apply before November 30, 2018.

We are seeking a highly ambitious, and skilled Research Associate to work within Prof. Paul Freemont's group at the Department of Medicine, Section of Structural Biology, which based in the Sir Alexander Fleming Building at our South Kensington campus.

The post holder will work on a recently awarded Imperial Confidence in Concept grant entitled 'A scalable approach for isolating therapeutic exosomes'. Exosomes are highly complex cell-derived nanovesicles that are secreted by many cell types and are thought to regulate physiological processes. There is a growing interest in developing therapeutic exosomes. However, current exosome isolation methods such as ultracentrifugation and precipitation-based protocols each have their own limitations which are hindering exosome research and inhibiting the large-scale manufacture of therapeutic exosomes. To this end, the post holder will support our efforts to generate and scale-up a novel immunocapture-based technology for isolating therapeutic exosomes. This will involve culturing industrially relevant mammalian cell lines (e.g. HEK293 suspension cells) using a hollow-fibre bioreactor system, cloning and testing libraries of exosome-capture tools, isolating exosomes (using both standard and our novel methods) and characterising these isolated exosomes (e.g. size, markers etc.).

Under the overall direction and supervision of the line manager and also key collaborators the post holder will apply and extend his/her knowledge of relevant molecular techniques, exosome biology, mammalian tissue culture and/or bioprocessing. In addition, the post-holder will also be expected to contribute to our other exosome research activities, as appropriate. The postholder will require a PhD in exosome biology, cancer biology, molecular biology, synthetic biology, bioprocess engineering or a closely related discipline, or equivalent research, industrial or commercial experience.

For more information about The Section of Structural Biology please visit: https://www.structurebiomed.org/

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