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PhD Scholarship Position in Yeast Genetics and Physiology

Applications are invited for a PhD position in molecular biology to join Chalmers University of Technology, Sweden. The initial contract for this position is five years. Applications are invited up to December 31, 2018.

The Department of Biology and Biological Engineering was founded January 1 2015, and started off with high ambitions. The aim was to grow and become a leading center of innovation by combining the latest research in life sciences with biochemistry. And the department got off to flying start. In its first year, the numbers for publication, citation and external funding have been excellent.

The department consists of four divisions, each conducting outstanding research in the areas of industrial biotechnology, systems biology, chemical biology and food science. The overall goal is to help build a sustainable society and improve human health. Nearly 200 people from 20 countries are currently working at the department. The working environment is characterized by respect, cooperation, responsibility, creativity and job satisfaction. The Department of Biology and Biological Engineering has summarized its mission in four points: - To be an attractive environment for top-level researchers in biological engineering - To deliver top-level research results and innovative solutions for use in a sustainable society - To offer excellent education that develops creative engineers and scientists - To be a major contributor to international visibility of Chalmers Information about the divison and the research

The PhD position is placed at the Division of Industrial Biotechnology within the Department of Biology and Biological Engineering at Chalmers University of Technology. The Industrial Biotechnology group is a young, dynamic and international group of researchers established in 2008 and counts now around 40 members. The common denominator of the research activities in the group is to optimize the use of renewable raw materials for the sustainable production of fuels, chemicals and materials within the main concept of biorefinery.

The research performed within the group spans from fundamental research, technology development and lab-scale application: this ensures deep knowledge of the studied systems, leading to rational development and optimization of the respective applications. The research fields include production of biofuels and chemicals via fermentation and enzymatic refining of biomass, bioelectrochemical systems and algal biotechnology. The division has an extensive instrument platform for analytics, molecular biology, protein production and purification, fermentation, including anaerobic systems, which are all available for the project. In addition, core facilities with advanced equipment are available within both the Department and at the University campus.

Information about the project

The focus of this project is to study stress regulation in yeast through metabolic engineering and the use of state-of the art methodologies such as CRISPR/Cas9, CRISPRi, ChIP-Seq and RNA-Seq. The work is expected to lead to novel insights in how the regulatory cascades of the cell influence its phenotype. In particular, we are interested in elucidating regulation mechanisms involved in robustness and tolerance towards inhibitors found in plant biomass derived raw materials.

A thorough understanding of cellular regulation is needed for the development of biotechnological production hosts, so-called cell factories. Efficient biochemical conversion of renewable carbon sources is crucial for the transition into a resource efficient society. Industrial processes require strains that are robust and tolerant to several stress conditions, features to be developed in order for biobased chemicals and materials to be price-competitive.

The project is funded by The Swedish Research Council.

Major responsibilities

The main task of the PhD student will be to build and evaluate a large number of Saccharomyces cerevisiae strains using CRISPR/Cas9 based genome editing and transcriptional regulation (CRISPRi), high-throughput screening systems and bioinformatics.

As a PhD student you will be expected to carry out independent research in line with the project described above, including laboratory work, and manuscript writing. You will be expected to share knowledge with MSc students and other colleagues and collaboration partners (Division of Systems Biology at Chalmers, Stanford Genome Centre in USA).

- take part in group responsibilities such as group meetings, literature presentations and floor duty

- take PhD student courses (60 ETCS is mandatory to obtain a PhD)

- present research at scientific meetings.

- take part in teaching activities such as course lab duty.

Your major responsibilities are to pursue your own doctoral studies. You are expected to develop your own scientific concepts and communicate the results of your research both verbally and in writing. The position generally also includes teaching on Chalmers’ undergraduate level or performing other duties corresponding to up to 20 per cent of working hours.

Full-time temporary employment.The position is limited to a maximum of five years.

Qualifications

The candidate must hold a MSc degree in Biotechnology/Bioengineering, Bioinformatics, Synthetic, Systems or Molecular Biology, Microbiology or other related disciplines. The successful candidate has knowledge on molecular biology and some lab practice as well as some knowledge in bioinformatics. Previous experience in working with sequencing data analysis, yeast physiology or high-throughput screening is a strong merit.

Most importantly, the candidate is self-motivated, enthusiastic and creative. To be successful in this position, you need to be well-organized and able to drive and conclude projects independently, take own initiatives, discuss/develop own ideas and enjoy solving problems. The project is in collaboration with other researchers and thus excellent cooperation and social abilities are highly important. Good communication skills in English are required.

Chalmers offers a cultivating and inspiring working environment in the dynamic city ofGothenburg.

Read more aboutworking at Chalmersand ourbenefitsfor employees.

Application procedure

The application should be marked with Ref 20180661 and written in English.

CV: (Please name the document: CV, Family name, Ref. number)

CV

Other, for example previous employments or leadership qualifications and positions of trust.

Two references that we can contact.

Personal letter: (Please name the document as: Personal letter, Family name, Ref. number)

1-3 pages where you introduce yourself and present your qualifications.

Previous research fields and main research results.

Future goals and research focus.Are there any specific projects and research issues you are primarily interested in?

Copies of bachelor and/or master's thesis.

Attested copies and transcripts of completed education, grades and other certificates, eg. TOEFL test results.

Application deadline: 31th of December 2018

Assistant Professor Yvonne Nygrd, yvonne.nygard@chalmers.se


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