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PhD Scholarship Position in Medical Science Translational Stroke Research

A fully-funded PhD fellowship in medical sciences is available at University of Gothenburg. This position is available for 4 years. This position is closed on November 28, 2018.

The PhD position will be within the research group of Professor Christina Jern at the Department of Pathology and Genetics, Institute of Biomedicine at the Faculty of Health Care Sciences at Sahlgrenska Academy, University of Gothenburg. The Institute of Biomedicine has a broad and extensive involvement in both research and education. In both of these areas focus is on increasing fundamental knowledge of the living cell - what it consists of, how it works, how its function is directed by the genetic material, and how it interacts with various kinds of micro-organisms. Using this knowledge, we try to elucidate the causes of diseases, and find new ways to diagnose and treat them. Our extensive education assignment comprises teaching at the medicine, pharmacy, dentistry and laboratory technology programs. At present, the institute has about 360 employees.

Project title: On the hemostatic pathway in stroke

General information about third-cycle studies: The PhD education in Medical Science corresponds to studies of 240 credits in total. The studies are equivalent to four year full-time and lead to a Degree of Doctor. The studies comprisecarrying out a scientific project and completing at least 30 credits of courses at third-cycle level. The doctoral student must also write a scientific compilation thesis or monograph corresponding to at least 120 credits. For more information about third-cycle studies at Sahlgrenska Academy, see https://medarbetarportalen.gu.se/sahlgrenskaakademin/forskarutbildning/?languageId=100001

Project: Stroke is a common disorder and the most common cause of acquired disability in adults. Ischemic stroke is caused by a blood clot in the majority of cases. This can occur in different ways, which means that there are different etiological subtypes of ischemic stroke, and knowledge is limited on mechanisms in these different subtypes.

The aims of this PhD project are to test the hypothesis that factors regulating blood clotting (hemostasis) are important for the risk of stroke, that the importance of hemostatic factors differ by etiological subtype, and to better understand the underlying mechanisms. The PhD student will investigate plasma levels of hemostatic proteins in ischemic stroke and seek to find subtype-specific patterns. These will then be used in order to investigate cryptogenic stroke, i.e. patients in whom no underlying cause of stroke can been identified despite extensive examination (Aim 1). The majority of coagulation factors are produced in the liver and the PhD student will study the importance of genetic variation for gene expression and functionally characterize selected variants in vitro (Aim 2). Finally, the student will investigate the association between these genetic variants and stroke and its subtypes (Aim 3). Methods include eg multiplex plasma protein analysis and next generation sequencing of DNA and RNA. We have broad international collaborations and the main supervisor is chairman of "Stroke Centrum Vst", a research network that arranges seminars for stroke researchers including PhD students. Thus, we can offer a very good interdisciplinary supervision in a translational research environment where a new PhD student can quickly come into contact with a wide network of stroke researchers and geneticists.

The PhD project is expected to provide new knowledge about the importance of hemostasis in stroke. In the long run, such knowledge will contribute to the development of precision medicine for stroke, i.e. more tailored care with personalized treatment and secondary prevention. For more information, please see http://biomedicine.gu.se/ominst/avd/genetik/forskare/christina-jern https://strokecentrumvast.gu.se To be eligible for third-cycle studies, the applicant must meet both the general and specific entry requirements.

A person meets the general entry requirements for third-cycle studiesif he or she:

1. has been awarded a second-cycle qualification 2. has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle, or 3. has acquired substantially equivalent knowledge in some other way in Sweden or abroad A person meets thespecific entry requirements for third-cycle studiesif he or she: has successfully completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies

In selecting between applicants who meet the general and specific entry requirements, their ability to benefit from third-cycle studies shall be taken into account. The assessment shall attach particular importance to documented qualifications for:

– specific knowledge and skills within the subject area and related research fields – experience of scientific theory and relevant research methodology – scientific analysis and presentation verified through thesis, degree project, scientific journals or the like. Great emphasis will be placed on personal suitability. We are looking for a PhD student with genuine interest in our research area, good ability to absorb and translate new knowledge and very good communication skills.

Time limited employment (temporary),4 years.Extent:100%. Location: Sahlgrenska Academy, Institute of Biomedicine, Department of Pathology and Genetics. First day of employment: as agreed.

Regulations for employment of doctoral students are given in SFS 1998:80.Only those who are admitted to third-cycle studies may be appointed to doctoral studentships. Those appointed to doctoral studentships shall primarily devote themselves to their studies. They may, however, work to a limited extent with educational tasks, research and administration according to the regulations.

The initial appointment may apply for no longer than one year. An appointment may be renewed for no more than two years at a time. The total employment period may not exceed the time corresponding to full-time third-cycle studies for four years.

Salaries for doctoral students are regulated in a local agreement at the University.

For more information about the project please contact

Principal supervisor,Christina Jern, Professor,+46 31 343 5720, christina.jern@gu.se

Assistant supervisor, Tara Stanne,+46 31 343 6526, tara.stanne@gu.se

Union representatives at the University of Gothenburg:

http://www.gu.se/english/about_the_university/job-opportunities/union-representatives In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. Attach verified copies of your education and English proficiency proving your eligibility. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline. The selection of candidates is made on the basis of the qualifications registered in the application.

The University of Gothenburg promotes equal opportunities, equality and diversity.

Salaries for doctoral students are regulated in a local agreement at the University.

Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.


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