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PhD Scholarship Position in Medical Science Lntestinal Glycoprotein Receptors of Cholera Toxin

University of Gothenburg, Sweden has an opening PhD position in medical sciences. Successful candidate will have funding to work and study for 4 years in Sweden. Applicants should apply before November 28, 2018.

The Department of Microbiology and Immunology is located at the Institute of Biomedicine at the Faculty of Health Care Sciences at Sahlgrenska Academy, University of Gothenburg. Research at the Department is conducted within microbiology and immunology,particularly at mucosal surfaces, and includes preclinical as well as clinical studies. The main research focus includes studies of the mechanisms of disease and immunity during various mucosal infections, vaccine research, adjuvant development and gastrointestinal disorders such as inflammatory bowel disease and colon cancer. Research in hematopoiesis, cellular ageing and protein quality control are also carried out at the department. Research is performed in close collaboration with Sahlgrenska University Hospital as well as research labs in Sweden, Europe, North and South America, Asia and Australia.

Project title: Functional characterization of novel enterotoxin receptors for the development of improved therapies and oral vaccines

General information about third-cycle studies: The PhD education in Medical Science corresponds to studies of 240 credits in total. The studies are equivalent to four year full-time and lead to a Degree of Doctor. The studies comprisecarrying out a scientific project and completing at least 30 credits of courses at third-cycle level. The doctoral student must also write a scientific compilation thesis or monograph corresponding to at least 120 credits. For more information about third-cycle studies at Sahlgrenska Academy, see https://medarbetarportalen.gu.se/sahlgrenskaakademin/forskarutbildning/?languageId=100001

Project: Diarrheal diseases kill annually 2.5 million children annually under the age of five. Available vaccines have limited protection. The vaccine against Cholera, a disease causing an estimated 1-4 million cases each year, has 65% efficacy.

The disease symptoms are due to the toxic effects of Cholera toxin (CT). Recently we have published findings that change the dogma for how CT binds tointestinal cells. Whereas the glycolipid GM1 was the only previously known functional receptor for CT, we discovered that CT intoxicates mice that lack GM1.https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006862.In addition, blocking fucosylated structures, not expressed by GM1, efficiently inhibits binding to and CT-induced secretion from human intestinal biopsies.https://elifesciences.org/articles/09545In addition to inducing a diarrheal response, CT is also very immune-activating and thereby a potent oral adjuvant. Hence, our findings of novel receptors for CT open up avenues for new blocking therapies as well as improved oral vaccines that are the two overall goals of this PhD project. The PhD student will specifically aim to: To be eligible for third-cycle studies, the applicant must meet both the general and specific entry requirements.

A person meets the general entry requirements for third-cycle studiesif he or she:

1. has been awarded a second-cycle qualification 2. has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle, or 3. has acquired substantially equivalent knowledge in some other way in Sweden or abroad A person meets thespecific entry requirements for third-cycle studiesif he or she: has successfully completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies

In selecting between applicants who meet the general and specific entry requirements, their ability to benefit from third-cycle studies shall be taken into account. The assessment shall attach particular importance to documented qualifications for:

– specific knowledge and skills within the subject area and related research fields – experience of scientific theory and relevant research methodology – scientific analysis and presentation verified through thesis, degree project, scientific journals or the like. Documented experiencein the field ofglycobiology and/or immunology, andprevious work with experimental animal research including immunizations, sample collections and microsurgical techniquesis valued.Experience in preparation of cells from tissues and subsequent in vitro experiments with primary cells andpractical cell culture experience preferably with organoids, is desirable.

Time limited employment (temporary),4 years.Extent:100%. Location: Sahlgrenska Academy, Institute of Biomedicine, Department of Microbiology and Immunology. First day of employment: as agreed.

Regulations for employment of doctoral students are given in SFS 1998:80.Only those who are admitted to third-cycle studies may be appointed to doctoral studentships. Those appointed to doctoral studentships shall primarily devote themselves to their studies. They may, however, work to a limited extent with educational tasks, research and administration according to the regulations.

The initial appointment may apply for no longer than one year. An appointment may be renewed for no more than two years at a time. The total employment period may not exceed the time corresponding to full-time third-cycle studies for four years.

Salaries for doctoral students are regulated in a local agreement at the University.

For more information about the project please contact theprincipal supervisor,

Ulf Yrlid, Associate Professor,+46 31 786 6225,ulf.yrlid@gu.se

Union representatives at the University of Gothenburg:

http://www.gu.se/english/about_the_university/job-opportunities/union-representatives In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. Attach verified copies of your education and English proficiency proving your eligibility. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline. The selection of candidates is made on the basis of the qualifications registered in the application.

The University of Gothenburg promotes equal opportunities, equality and diversity.

Salaries for doctoral students are regulated in a local agreement at the University.

Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.


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