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PhD Scholarship Position in Medical Science Transmembrane Mucins in Host-microbe Interactions

Applications are invited for a PhD position in medical sciences to join University of Gothenburg. The funding allows successful candidate to work for 4 years. Candidates are welcome before November 28, 2018.

Project title: The role of transmembrane mucin MUC17 in host surveillance of gut microbiota

General information about third-cycle studies: The PhD education in Medical Science corresponds to studies of 240 credits in total. The studies are equivalent to four year full-time and lead to a Degree of Doctor. The studies comprisecarrying out a scientific project and completing at least 30 credits of courses at third-cycle level. The doctoral student must also write a scientific compilation thesis or monograph corresponding to at least 120 credits. For more information about third-cycle studies at Sahlgrenska Academy, see

https://medarbetarportalen.gu.se/sahlgrenskaakademin/forskarutbildning/?languageId=100001

Project: The emerging importance of host-microbe interactions for our health gives urgency to understanding how host intestinal epithelial cells sense gut microbes in health and disease. Long, extended transmembrane mucins cover the entire apical brush border of epithelial cells of the small and large intestines. Our long-term goal is to elucidate the fundamental function of intestinal transmembrane mucins and to understand how transmembrane mucins assist host epithelial cells in surveillance of the gut microbiota.

Our central hypothesis is that intestinal microbiota promotes transmembrane mucin expression on epithelial membranes. This allows for transmembrane mucins to capture specific microbiota-derived ligands and to signal back to the innate immune system in order to promote appropriate host responses against the microbiota. The doctoral project aims to identify the signaling pathways that regulate transmembrane mucin expression and to define the crosstalk between signaling downstream of transmembrane mucins and host epithelial innate immunity. The research project is translational and involves investigations in cell lines and experimental animal models as well as human-derived organoids and patient biopsies. The methods utilized in the project include cell culture, in vivo protein labeling and proteomics combined with advanced imaging techniques. To be eligible for third-cycle studies, the applicant must meet both the general and specific entry requirements.

A person meets the general entry requirements for third-cycle studiesif he or she:

1. has been awarded a second-cycle qualification 2. has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle, or 3. has acquired substantially equivalent knowledge in some other way in Sweden or abroad A person meets thespecific entry requirements for third-cycle studiesif he or she: has successfully completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies

In selecting between applicants who meet the general and specific entry requirements, their ability to benefit from third-cycle studies shall be taken into account. The assessment shall attach particular importance to documented qualifications for:

– specific knowledge and skills within the subject area and related research fields – experience of scientific theory and relevant research methodology – scientific analysis and presentation verified through thesis, degree project, scientific journals or the like. Documented experience in the field of mucin biology, intestinal physiology, cell biology or related field isof value, as well as in confocal imaging with an interest in applying technical skills on organoids and animal models for intestinal inflammation.Good communication skills, and a very high level of commitment and curiosity regarding the mucin biology field are desirable.

Time limited employment (temporary),4 years.Extent:100%. Location: Sahlgrenska Academy, Institute of Biomedicine, Department of Medical Biochemistry and Cell biology. First day of employment: as agreed.

Regulations for employment of doctoral students are given in SFS 1998:80.Only those who are admitted to third-cycle studies may be appointed to doctoral studentships. Those appointed to doctoral studentships shall primarily devote themselves to their studies. They may, however, work to a limited extent with educational tasks, research and administration according to the regulations.

The initial appointment may apply for no longer than one year. An appointment may be renewed for no more than two years at a time. The total employment period may not exceed the time corresponding to full-time third-cycle studies for four years.

Salaries for doctoral students are regulated in a local agreement at the University.

For more information about the project please contact theprincipal supervisor,

Thaher Pelaseyed, thaher.pelaseyed@medkem.gu.se Union representatives at the University of Gothenburg:

http://www.gu.se/english/about_the_university/job-opportunities/union-representatives

In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. Attach verified copies of your education and English proficiency proving your eligibility. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline. The selection of candidates is made on the basis of the qualifications registered in the application.

The University of Gothenburg promotes equal opportunities, equality and diversity.

Salaries for doctoral students are regulated in a local agreement at the University.

Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.


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