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PhD Scholarship in Medical Radiation Physics at Lund University

Lund University is delighted to offer a PhD position in environmental sciences. The initial contract for this position is four years. Potential candidates should apply before November 30, 2018.

The Faculty of Science conducts research and education within Biology, Astronomy, Physics, Geosciences, Chemistry, Mathematics and Environmental Sciences. The Faculty is organized into nine departments, gathered in the northern campus area. The Faculty has approximately 1500 students, 330 PhD students and 700 employees.

The department of Medical Radiation Physics is engaged in research and education in ionizing and non-ionizing radiation, and its use mainly in medical applications. The major areas are magnetic resonance imaging (MRI), radiation therapy, X-ray physics, and nuclear medicine.

The MR physics research group (www.med.lu.se/klinvetlund/MR_physics), situated in the expanding resund region in southern Sweden, is active in the field of medical magnetic resonance, and has its primary focus on development of new techniques for assessment of functional information related to perfusion, diffusion, cortical activation/fMRI and flow. Emerging areas in the group encompass high field-studies using CEST as well as quantitative MRI in the brain and in the musculoskeletal system.

We are looking for a Ph.D. student in Medical Radiation Physics with a focus on MR-Physics.

We intend to use natural sugar (D-glucose) as a biodegradable agent for diagnosing cancer with MRI. D-glucose is a regulatory approved biocompatible substance that is already used in glucose tolerance testing of diabetics in the clinic. Injection of small amounts of glucose will not change conventional MRI contrast. However, we will accomplish detection using a novel approach called CEST (chemical exchange saturation transfer) MRI. Using CEST, the presence of small (millimolar) amounts of glucose can be detected with greatly enhanced sensitivity through the water signal by using its hydroxyl protons as a natural label that exchanges with water protons.

The main assignment is to develop and apply the glucose CEST ("glucoCEST") method in healthy volunteers and in patients with brain cancer in order to evaluate its use for the combined imaging of perfusion and permeability in tumours. More specifically, the tasks are to optimize imaging parameters, implement post-processing methods and to develop methods for tracer-kinetic analysis of glucoCEST data.

Students with basic eligibility for third-cycle studies are those who have either completed a second-cycle degree, or completed courses of at least 240 credits, of which at least 60 credits are from second-cycle courses, or acquired largely equivalent knowledge in some other way, in Sweden or abroad.

Additionally, to be accepted for third-cycle studies in Medical Radiation Physics the applicant must have a MSc degree in Medical Physics (or an equivalent foreign degree), or completed an alternative university education to achieve basic eligibility equivalent to 240 credits, of which courses of at least 60 credits are directly relevant for the doctoral studies announced here, and has completed a research project thesis (MSc thesis, or equivalent) corresponding to at least 30 credits.

Admission to third level (doctoral) studies is based primarily on the evaluated ability of the student to pursue and benefit from such studies.

Type of employment

Limit of tenure, four years according to HF 5 kap 7. The application is to be made online. An incomplete applicationwillnot be processed.


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