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PhD in Translational Cancer Research at Lund University

Lund University is offering PhD position in oncology. The initial contract for this position is four years. The deadline to apply is December 02, 2018.

The Faculty of Medicine is a part of Lund University, and is responsible for education and research within medicine and healthcare. Our academic programs are closely linked with the healthcare system and are firmly anchored in the faculty's strong research tradition. Our research spans a broad field within experimental preclinical research, near-patient clinical research and health sciences research. The Faculty of Medicine, with its 1,800 employees and 2,700 students in Lund and Malm, is a knowledge-intensive meeting place for students, teachers and researchers from all over the world.

The Department of Laboratory Medicine is one of six departments at Lund University's Faculty of Medicine. We conduct leading research, both broad and specialised, within the field of laboratory medicine, focusing on the onset of disease and how we can improve diagnostics and treatment for patients. Some of our strongest areas with world-class research deal with cancer, genetics and blood.

Within the Molecular Pediatric Oncology research lab we work to understand and target childhood cancer neuroblastoma. Neuroblastoma is a solid childhood tumor derived from the sympathetic nervous system. It is responsible for 15% of pediatric cancer deaths and is characterized by its heterogeneity, ranging from benign forms to aggressive types with distant metastatic spread. Patients with aggressive neuroblastoma have a very poor prognosis, even with surgery and treatment with high-dose chemotherapy.

We have established patient-derived orthotopic xenograft (PDX) models by implanting neuroblastoma tissue into mice. These PDXs retain the histology and genetic aberrations of their original patient tumor and they have the ability to metastasize to distant organs, including bone marrow. We have also established human neuroblastoma in vitro cultures from the PDX tumors, which have shown to be more relevant and predictive as compared to conventional cell lines.

With these PDX models and PDX-derived cell lines, we have the opportunity to test novel drugs that could improve the treatment of neuroblastoma. We have previously performed a high-throughput drug screen where we identified several novel drugs with potent effect against neuroblastoma. The current project aims to further examine the effects and mechanisms of these selected drugs.

Work duties

- Take part in the laboratory work and develop methods connected to the project

- Write articles and publications together with the supervisor

- Take part in everyday laboratory planning and meetings as well as participate in journal clubs and workshops, seminars and conferences

- Some administrative duties may occur

- Some teaching may occur

- Take part in the doctoral courses provided by the department and the faculty

Qualifications

The applicant must be highly talented and highly ambitious, have very good reading comprehension and writing skills and have a great motivation for the subject. The applicant should have knowledgeand documented experience within the field of laboratory medicine in general and in bio medicine and cancer mikro biology in particular.

Qualifying merits

Knowledge of neuroblastoma, in vitro drug testing, prior experience with culturing and drug testing of patient-derived cells is also desirable. The applicant should also be fluent in English.

Emphasis will be placed on personal suitability

Eligibility

Students with basic eligibility for third-cycle studies are those who- have completed a second-cycle degree- have completed courses of at least 240 credits, of which at least 60 credits are from second-cycle courses, or- have acquired largely equivalent knowledge in some other way, in Sweden or abroad.

The employment of doctoral students is regulated in the Swedish Code of Statues 1998: 80. Only those who are or have been admitted to PhD-studies may be appointed to doctoral studentships. When an appointment to a doctoral studentship is made, the ability of the student to benefit from PhD-studies shall primarily be taken into account. In addition to devoting themselves to their studies, those appointed to doctoral studentships may be required to work with educational tasks, research and administration, in accordance with specific regulations in the ordinance.

Type of employment

Limit of tenure, four years according to HF 5 kap 7.

Summary:

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