Postdoctor at Lund University

A new opening postdoctoral position in bioinformatics is available at Lund University, Sweden. The initial contract for this position is three years. Applications are welcome before November 01, 2018.

The Faculty of Medicine is a part of Lund University, and is responsible for education and research within medicine and healthcare. Our academic programs are closely linked with the healthcare system and are firmly anchored in the faculty's strong research tradition. Our research spans a broad field within experimental preclinical research, near-patient clinical research and health sciences research. The Faculty of Medicine, with its 1,800 employees and 2,700 students in Lund and Malm, is a knowledge-intensive meeting place for students, teachers and researchers from all over the world.

The Department of Laboratory Medicine is one of six departments at Lund University's Faculty of Medicine. We conduct leading research, both broad and specialised, within the field of laboratory medicine, focusing on the onset of disease and how we can improve diagnostics and treatment for patients. Some of our strongest areas with world-class research deal with cancer, genetics and blood.

The Division of Clinical Genetics is now hiring a postdoctoral fellow for a project untangling how selection from the tumor microenvironment shapes the clonal landscape of cancer! The Cancer Crossroads Project is funded by the LMK Foundation and hosted by Lund University in Sweden. You will join a small team of scientists working at the interface of evolutionary ecology, computer modelling and cancer genomics. We employ these disciplines to build novel treatment concepts for childhood tumors, in particular neuroblastoma, rhabdomyosarcoma and Wilms tumor. By detailed multi-regional sampling followed by analysis of copy number and sequence data, we construct cancer cell phylogenies and deduce evolutionary trajectories. A recent example of our work can be found in Nature Genetics 2018 (50:944-950). Work duties:

Your focus will be to apply and develop computational tools to unravel how todays' cancer treatments and the patient's own immune response shape the genome of cancer cells through Darwinian selection. Your main challenge will be to compare mutational patterns to multi-regional data on the tumor micro-environment, such as estimates of chemotherapy effect and RNA expression signatures of immune response. As a first step, you will have to adapt publicly available scripts for phylogenetic analysis and evaluation of selection to childhood cancer mutational signatures dominated by large-scale chromosomal alterations. Qualification:

We are looking for someone with a PhD within medicine, science or a technical subject. The PhD must have been completed within the last three years, with time deductions according to the Swedish Research Council s regulations. You also need basic knowledge in computer programming with at least one programming language used for biomedical applications to be consider for this position. If you have knowledge and/or educations within bioinformatics, programming, cancer research, population genetics, cancer genetics and/or mathematical biology, this will be considered meritorious. Do you also have previous knowledge about the management of large-scale genetic data and experience of computer simulations of biological systems that will also be advantageous. You as a person needs to be able to work with others in a group with the aim of reaching the answer to a research question. We consider it important that you can both provide constructive feedback to others and act constructively on feedback given to you. We also see you as someone that can work independently with problem solving without losing focus of the project's aims. Great emphasis will be placed on personal suitability.


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