PhD Studentship Genomic and Functional Analysis of Mutational Processes in High Grade Serous Ovarian Carcinoma

A fully-funded PhD fellowship in computational biology is available at University of Cambridge. Eligible candidates should submit the applications before November 15, 2018.

The Cancer Research UK Cambridge Institute (CRUK CI) is a joint venture between the Charity, Cancer Research UK, and the University of Cambridge. The Institute has excellent state-of-the-art facilities and research ranges from basic cancer biology and computational biology through to translational research and clinical application.

Graduate students play a pivotal role in the continuing success of our research programmes and gaining a studentship in the Institute is an excellent opportunity to start a research career in an environment committed to training outstanding cancer research scientists of the future.

Dr James Brenton, Head of the Functional genomics of ovarian cancer research group, wishes to appoint a student to work on the project entitled: Genomic and functional analysis of mutational processes in high grade serous ovarian carcinoma.

High grade serous ovarian carcinoma (HGSOC) has an extremely poor outcome with a mortality/incidence ratio that is similar to lung and pancreatic cancer [1]. The development of precision medicine in HGSOC has significantly lagged behind other cancer types, in part because HGSOC has the most complex genome of all epithelial neoplasms. This has impeded molecular understanding of the disease and robust classifications for therapy.

Our laboratory has focused on identifying mutational processes in HGSOC to understand how divergent evolution occurs in patients as a rational basis to develop improved diagnostic and therapeutic approaches for precision medicine [2, 3]. We have identified distinct mutational signatures in HGSOC that show significant associations with known driver gene mutations and predict resistance to therapy [4]. Copy number signatures provide a new framework to understand and quantify mutational processes in a single cancer and show that HGSOC comprises a continuum of genomes shaped by multiple mutational processes.

This project will focus on the molecular characterization of specific copy number signatures to identify new driver mechanisms and novel approaches for treatment using both genomic (single cell, long read sequencing) and functional approaches. In vitro and in vivo work will use HGSOC organoid and PDX model systems developed in our lab.

This project is ideal for candidates seeking experience in transitional research and the post holder will work in a multidisciplinary team of wet and dry laboratory staff, clinicians and members of the Cambridge Centre Ovarian Programme. A strong background in genomics and computational methods would be an advantage. The project will provide training in next generation sequencing, bioinformatic analysis, experimental design and functional genomics.

This project is funded by a Cancer Research UK studentship that includes full funding for University and College fees and a stipend of 19,000 per annum.

No nationality restrictions apply to Cancer Research UK funded studentships. Applications are invited from recent graduates or final year undergraduates who hold or expect to gain a first/upper second class degree (or equivalent) in a relevant subject from any recognised university worldwide.

All applications need to be made using the University Applicant Portal. Please visit: for further information about the course and to access the applicant portal.

To complete your on-line application, you need to provide the following: Reference Request: The names and contact details of two academic referees who have agreed to act on your behalf.

Research: If you wish to be considered for more than one studentship, please enter the names of all of the supervisors you wish to consider your application in the ‘Research summary’ text box. If you only wish your application to be considered by a single supervisor, then please enter their name in the ‘Research Supervisor’ text box. Please describe your past ‘Research experience’ in the appropriate text box.

Course Specific Questions: Your statement of interest (limit of 2,500 characters) should explain why you wish to be considered for the studentship and which qualities and experience you will bring to the role. Please also state how you learned of the studentship.

Supporting Documents: Please upload your CV (PDF file), which should include a list of the examinations taken at undergraduate level and if possible, your examination results

Deadline The closing date for applications is 15 November 2018, with interviews expected to take place in December/January.


Get latest scholarships via your email! It's free!
Remember to check your email and active the subscription.
You can unsubscribe any time.
Copyright © 2019 All Right Reserved.