PhD Studentship Elucidating The Roles of Rna-protein Regulatory Networks in Centrosome Biology and The Cell Cycle

University of Cambridge, UK is inviting applicants to apply for a PhD position in computational biology. Eligible candidates should submit the applications before November 15, 2018.

The Cancer Research UK Cambridge Institute (CRUK CI) is a joint venture between the Charity, Cancer Research UK, and the University of Cambridge. The Institute has excellent state-of-the-art facilities and research ranges from basic cancer biology and computational biology through to translational research and clinical application.

Graduate students play a pivotal role in the continuing success of our research programmes and gaining a studentship in the Institute is an excellent opportunity to start a research career in an environment committed to training outstanding cancer research scientists of the future.

Dr Fanni Gergely, Head of the Centrosomes, microtubules and Cancer research group, wishes to appoint a student to work on the project entitled: Elucidating the roles of RNA-protein regulatory networks in centrosome biology and the cell cycle.

Our research aims to elucidate the molecular mechanisms that control cell division in development and cancer. In several tissues, centrosomes act as key microtubule organizing centres both in proliferating and differentiated cells. Moreover, because centrosomes organise the mitotic spindle poles and template the assembly of primary cilia (signalling organelles with diverse functions), centrosome numbers must be strictly controlled in cells. Indeed, in cultured cells and during development, both loss and gain of centrosomes can lead to mitotic delay, chromosomal instability, cell cycle arrest and apoptosis. Centrosome amplification can also initiate invasion and tumourigenesis. The goal of this project is to test the hypothesis that centrosomes exhibit tissue-specific roles, especially in cell cycle control. The work will involve identification and characterisation of new RNA-protein regulatory networks underscoring these functions. Proteomics, molecular biology and microscopy imaging will be integral to the success of the project.

A degree in biochemistry, molecular or cell biology is essential and previous research experience is desired.

This project is funded by a Cancer Research UK studentship that includes full funding for University and College fees and a stipend of 19,000 per annum.

No nationality restrictions apply to Cancer Research UK funded studentships. Applications are invited from recent graduates or final year undergraduates who hold or expect to gain a first/upper second class degree (or equivalent) in a relevant subject from any recognised university worldwide.

All applications need to be made using the University Applicant Portal. Please visit: for further information about the course and to access the applicant portal.

To complete your on-line application, you need to provide the following:

The names and contact details of two academic referees who have agreed to act on your behalf.

If you wish to be considered for more than one studentship, please enter the names of all of the supervisors you wish to consider your application in the ‘Research summary’ text box. If you only wish your application to be considered by a single supervisor, then please enter their name in the ‘Research Supervisor’ text box. Please describe your past ‘Research experience’ in the appropriate text box.

Your statement of interest (limit of 2,500 characters) should explain why you wish to be considered for the studentship and which qualities and experience you will bring to the role. Please also state how you learned of the studentship. Supporting Documents: Please upload your CV (PDF file), which should include a list of the examinations taken at undergraduate level and if possible, your examination results.

The closing date for applications is 15 November 2018, with interviews expected to take place in December/January.


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