PhD Studentship Characterising Hedgehog Signalling in Immune Cells

Outstanding international students are invited to apply for a PhD scholarship in computational biology at University of Cambridge. Applications should be sent before November 15, 2018.

The Cancer Research UK Cambridge Institute (CRUK CI) is a joint venture between the Charity, Cancer Research UK, and the University of Cambridge. The Institute has excellent state-of-the-art facilities and research ranges from basic cancer biology and computational biology through to translational research and clinical application.

Graduate students play a pivotal role in the continuing success of our research programmes and gaining a studentship in the Institute is an excellent opportunity to start a research career in an environment committed to training outstanding cancer research scientists of the future.

Dr Maike de la Roche, Head of the Cancer immunology research group, wishes to appoint a student to work on the project entitled: Characterising Hedgehog signalling in immune cells.

During an anti-tumour response mature immune cells can differentiate into multiple different effector cell types. Signalling pathways driving this differentiation are poorly understood. The Hedgehog (Hh) signalling pathway has important roles during embryonic development, in adult tissue maintenance, and the generation of various immune cell types. By contrast, cell-intrinsic Hh signalling in mature peripheral immune cells is poorly understood. This project aims to elucidate how Hh signalling is orchestrated in mature immune cells and influences their development throughout the anti-tumour response in vivo.

The research project will involve the use of in vivo models, culture and genetic manipulation of primary immune cells, live cell imaging approaches, RNA-Sequencing, quantitative proteomics, FACS as well as basic cell biology and biochemistry.

The ideal candidate will have a solid knowledge of immunology and experience in one or more of the areas mentioned above. He or she must be highly motivated to drive an independent research project.

This project is funded by a Cancer Research UK studentship that includes full funding for University and College fees and a stipend of 19,000 per annum.

No nationality restrictions apply to Cancer Research UK funded studentships. Applications are invited from recent graduates or final year undergraduates who hold or expect to gain a first/upper second class degree (or equivalent) in a relevant subject from any recognised university worldwide.

All applications need to be made using the University Applicant Portal. Please visit: for further information about the course and to access the applicant portal.

To complete your on-line application, you need to provide the following: Reference Request: The names and contact details of two academic referees who have agreed to act on your behalf.

If you wish to be considered for more than one studentship, please enter the names of all of the supervisors you wish to consider your application in the ‘Research summary’ text box. If you only wish your application to be considered by a single supervisor, then please enter their name in the ‘Research Supervisor’ text box. Please describe your past ‘Research experience’ in the appropriate text box.

Your statement of interest (limit of 2,500 characters) should explain why you wish to be considered for the studentship and which qualities and experience you will bring to the role. Please also state how you learned of the studentship. Supporting Documents: Please upload your CV (PDF file), which should include a list of the examinations taken at undergraduate level and if possible, your examination results.

The closing date for applications is 15 November 2018, with interviews expected to take place in December/January.


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