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PhD Scholarship in Analytical Measurements of Exocytosis and Vesicles

University of Gothenburg, Sweden is inviting applicants to apply for a PhD position in medicinal chemistry. This position is available for 5 years. Applicants should apply before November 15, 2018.

PhD student in Analytical Measurements of Exocytosis and Vesicles

Research and graduate education at the department of chemistry and molecular biology comprises a wide scientific field from the atomic and molecular levels all the way through cells to intact organisms. Much of the phenomena studied here impact on our natural environment and living systems. We participate in undergraduate programs in chemistry, molecular biology, medicinal chemistry, biology, marine sciences, and pharmacy.

A third cycle education at our department will lead to a Ph.D. in Natural sciences, or Natural sciences with a specialisation in Chemistry, Biology or Biophysics. Ph.D. studies comprises four years at the post graduate level. The time period can be extended to 5 years in total through teaching and/or other departmental duties.

Information about the research group: Check our website: http://andrewewinggroup.se

More details on our research can be found at http://www.cmb.gu.se and soon at http://care.gu.se.

The PhD student will take classes and work on research projects in the laboratory to combine electrochemistry, STED super-resolution microscopy, and perhaps mass spectrometry imaging to study the transmitter composition in single vesicles. The student will also place a nanometer tip of a flame-etched electrode inside one of these neuronal varicosities (1-2 um size) to carry out our new technique, intracellular vesicle impact electrochemical cytometry (IVIEC) to quantify the transmitter content of vesicles in neurons and compare to that released to test the partial release hypothesis. The student will then explore a range of messenger released fractions from processed neurons in the fruit fly (Drosophila) brain comparing IVIEC and release to explore our overall model of partial release and plasticity under conditions where learning should be different. This goal is aimed at nerve cells in an organism versus the model cell lines, hence it should be considerably more similar to the human brain. If successful, this will significantly advance our understanding of complex exocytosis events and Drosophila will be the model used to study cell membrane lipid changes during plasticity in separate imaging experiments with NanoSIMS mass spectrometry and with STED super resolution microscopy.

The work in the laboratory is financed from grants from the European Research Council, the Knut and Alice Wallenberg Foundation, and the Swedish Research Council (VR).

1. has been awarded a second-cycle qualification, 2. has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle, or 3. has acquired substantially equivalent knowledge in some other way in Sweden or abroad. To meet the specific entry requirements for third-cycle studies, applicants must: (i) have a second-cycle (advanced-level) degree in a relevant* subject area in the natural sciences, or (ii) have completed studies for at least 60 higher education credits at a second-cycle level in relevant subject areas in the natural sciences, or (iii) have completed a corresponding programme of relevance to the planned third-cycle programme, in Sweden or in another country, or have equivalent qualifications. The specific entry requirements also include an acceptable command of spoken and written English. Guidelines for assessing English proficiency may include a minimum score of 550 on the TOEFL test (or 213 on the TOEFL-CBT, or 79 on the TOEFL-iBT).

Regulations for the evaluation of qualifications for education on a doctoral level are given in SFS 1998:80.

Additional information about the assessment: Excellence, creativity, and a personality that is easy to work with are the main criteria. It is preferred that the candidate has some experience with electrochemistry, STED microscopy, and/or cell measurements.

Type of employment: Fixed-term employment, Four years full time

Extent: 100 % Location: Department of Chemistry and Molecular Biology, Gothenburg First day of employment: 2019-12-15 Regulations for the evaluation of qualifications for education on a doctoral level are given in SFS 1998:80.

A new employment as a PhD student applies for a maximum of one year. The Appointment may be prolonged for up to two years at a time. The total employment period may not be longer than the equivalent of four years of full time time doctoral studies.

Cover letter with an explanation of why you apply for the position

CV including scientific publications Copy of exam certificate Two references (name, telephone no, relation) Andrew Ewing, Professor, andrewe@chem.gu.se.

Questions regarding the third-cycle education: Martin Billeter, Director of third cycle education, +46(0) 31-786 3925, martin.billeter@gu.se Questions regarding the employment: hr@cmb.gu.se Union representatives at the University of Gothenburg: http://www.gu.se/english/about_the_university/job-opportunities/union-representatives

In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline. The selection of candidates is made on the basis of the qualifications registered in the application.

The University of Gothenburg promotes equal opportunities, equality and diversity.

Salaries for doctoral students are regulated in a local agreement at the University.

Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.


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