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PhD Position in Systems Biotechnology at The Technical University of Munich

Applicants are invited to apply for a PhD position in molecular biology at Technical University of Munich. There is no application deadline for this position.

The group of Systems Biotechnology (SBT) at the Technical University of Munich focuses on application of methods from systems biology to problems related to biotechnology. Besides the improvement of the overall biotechnological processes, the better understanding of the processes inside the cell is a major research topic. The interdisciplinary group stands at the interface of mathematical modelling and experimental work in the wet lab. The mission: Pseudomonas putida is an important workhorse for contemporary biotechnological applications, as it combines easy handling and fast growth with a low nutrient demand and an intrinsic resistance to metabolic and physiological stresses. We aim to achieve a comprehensive, system-level understanding of the physiology and metabolism of heterologous protein overproduction in P. putida. Indeed, the induction of protein overproduction leads to a switch in resource allocation from the normal cellular functions towards the additionally implemented task. These resources comprise not only the transcriptional and translational machinery, but also chemical and redox energy. To face this new resource distribution, the metabolism as a whole has to adapt to ensure growth or at least the survival of the cells. If this fails, meaning that any of these resources becomes limiting, usually the growth rate decreases and heterologous production ceases. This phenomenon is referred to as `metabolic burden. You will employ P. putida to tackle fundamental and generic questions of heterologous protein biosynthesis or synthetic gene expression. What are the processes taking place during heterologous protein production and where are the bottlenecks? Does production cease because a specific resource becomes limiting? Can this information be generalized and eventually predicted? Your profile: - Master degree or similar in Microbiology, Molecular Biology, Biotechnology or related discipline. - Excellent academic records. - Strong motivation, scientific curiosity and commitment to scientific excellence. - Previous experience in mathematical modelling of cellular systems. - Good skills in molecular microbiology. - Team player skills and enthusiasm to work in a multi-disciplinary, collaborative environment. Our offer: The Technical University of Munich (TUM) stands for scientific excellence and innovation. This is your opportunity to be part of an interdisciplinary research group, where mathematical modelling and experimental work go hand in hand to develop the solutions of tomorrow. The Systems Biotechnology group provides a multidisciplinary environment offering excellent opportunities for professional growth. We support career development, continuing education and teaching and training opportunities. The successful applicant will have a third-party funded 3-year contract earliest starting in January 2019. The salary will be commensurate with work experience and seniority (TV-L E13). As an equal opportunity and affirmative action employer, TUM explicitly encourages applications from women. Preference will be given to disabled candidates with essentially the same qualifications. Contact: Please send your up-to-date and complete application file with cover letter, curriculum vitae, certificates and references per email to Prof. Dr. Andreas Kremling (a.kremling@lrz.tum.de, phone: +49 89 289 15760) or Dr. Katharina Pflger-Grau (k.pflueger-grau@lrz.tum.de, phone: +49 289 15765).

The group of Systems Biotechnology (SBT) at the Technical University of Munich focuses on application of methods from systems biology to problems related to biotechnology. Besides the improvement of the overall biotechnological processes, the better understanding of the processes inside the cell is a major research topic. The interdisciplinary group stands at the interface of mathematical modelling and experimental work in the wet lab. The mission: Pseudomonas putida is an important workhorse for contemporary biotechnological applications, as it combines easy handling and fast growth with a low nutrient demand and an intrinsic resistance to metabolic and physiological stresses. We aim to achieve a comprehensive, system-level understanding of the physiology and metabolism of heterologous protein overproduction in P. putida. Indeed, the induction of protein overproduction leads to a switch in resource allocation from the normal cellular functions towards the additionally implemented task. These resources comprise not only the transcriptional and translational machinery, but also chemical and redox energy. To face this new resource distribution, the metabolism as a whole has to adapt to ensure growth or at least the survival of the cells. If this fails, meaning that any of these resources becomes limiting, usually the growth rate decreases and heterologous production ceases. This phenomenon is referred to as `metabolic burden. You will employ P. putida to tackle fundamental and generic questions of heterologous protein biosynthesis or synthetic gene expression. What are the processes taking place during heterologous protein production and where are the bottlenecks? Does production cease because a specific resource becomes limiting? Can this information be generalized and eventually predicted? Your profile: - Master degree or similar in Microbiology, Molecular Biology, Biotechnology or related discipline. - Excellent academic records. - Strong motivation, scientific curiosity and commitment to scientific excellence. - Previous experience in mathematical modelling of cellular systems. - Good skills in molecular microbiology. - Team player skills and enthusiasm to work in a multi-disciplinary, collaborative environment. Our offer: The Technical University of Munich (TUM) stands for scientific excellence and innovation. This is your opportunity to be part of an interdisciplinary research group, where mathematical modelling and experimental work go hand in hand to develop the solutions of tomorrow. The Systems Biotechnology group provides a multidisciplinary environment offering excellent opportunities for professional growth. We support career development, continuing education and teaching and training opportunities. The successful applicant will have a third-party funded 3-year contract earliest starting in January 2019. The salary will be commensurate with work experience and seniority (TV-L E13). As an equal opportunity and affirmative action employer, TUM explicitly encourages applications from women. Preference will be given to disabled candidates with essentially the same qualifications. Contact: Please send your up-to-date and complete application file with cover letter, curriculum vitae, certificates and references per email to Prof. Dr. Andreas Kremling (a.kremling@lrz.tum.de, phone: +49 89 289 15760) or Dr. Katharina Pflger-Grau (k.pflueger-grau@lrz.tum.de, phone: +49 289 15765).

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