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PhD on Post Translational Modifications of Therapeutic Proteins

International students are invited for a PhD scholarship in molecular biology at Technical University of Denmark. The funds for this fellowship are available for 3 years. Candidates are welcome before November 02, 2018.

Applications are invited for a 3-year PhD fellowship on understanding the molecular interactions that produce post translational modifications of secreted proteins and applying that knowledge towards production of pharmaceutical biologics. The project will be carried out at the Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark (DTU) in the CHO cell line engineering and development group under supervision of Dr. Lasse Ebdrup Pedersen.

The mammalian bio-pharmaceutical industry produces therapeutic proteins to treat numerous diseases such as cancer, anemia and haemophilia. The most used mammalian cell factory is the Chinese hamster ovary (CHO) cell. Our group is a world leading CHO research group and we seek to improve our understanding of basic cell biology in the area of protein production and to apply that knowledge to predictably produce high quantity and high quality therapeutic proteins.

Responsibilities and tasks

The candidate will do research in the area of post-translational modifications during protein production. The candidate will employ advanced molecular biology tools and the latest -omic technologies, including genomics, proteomics and data analysis.

The PhD study also comprises courses equivalent to 30 ECTS credits and an international secondment of 3-6 months duration.

Qualifications

Candidates should have a master’s degree in engineering or a similar degree with an academic level equivalent to the master’s degree in engineering. A degree in Molecular biology, Biotechnology or similar is preferred.

Approval and Enrolment

The scholarship for the PhD degree is subject to academic approval, and the candidate will be enrolled in one of the general degree programmes at DTU. For information about our enrolment requirements and the general planning of the PhD study programme, please see the DTU PhD Guide.

Assessment

The assessment of the applicants will be made by Lasse Ebdrup Pedersen.

We offer

DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and appointment terms

The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. The period of employment is 3 years.

You can read more about career paths at DTU here.

Workplace will be at DTU Lyngby Campus.

Further information

Further information may be obtained from Dr. Lasse Ebdrup Pedersen, laeb@biosustain.dtu.dk.

You can read more about DTU Biosustain at www.biosustain.dtu.dk.

Application

Please submit your online application no later than 2 November 2018 (local time). Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link “Apply online”, fill out the online application form, and attach all your materials in English in one PDF file.

Candidates may apply prior to obtaining their master’s degree but cannot begin before having received it.

All interested candidates irrespective of age, gender,race, disability, religion or ethnic background are encouraged to apply.

The Novo Nordisk Foundation Center for Biosustainability is an international research center at the Technical University of Denmark primarily funded by a grant from the Novo Nordisk Foundation. The center conducts research in engineering of cell factories and in silico systems biology, with the purpose of developing new processes and technologies that can support a more sustainable bio-based production of valuable chemicals in the future. The center brings together some of the world’s leading researchers in the field and possesses the advanced equipment and facilities required for achieving its ambitious research goals. Impact on society by innovation has a high priority and the center collaborates worldwide with biotech companies and chemical industries to facilitate the dissemination and exploitation of its results.


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