PhD Candidate Metabolic Profiling of Volume-restricted Biological Samples

Leiden University is offering PhD position in environmental sciences. Successful candidate will have funding to work and study for two years in Netherlands. Applicants should apply as soon as possible.

In present-day metabolomics, advanced analytical separation techniques are used for the global profiling of (endogenous) metabolites in biological samples. A key challenge, in this context, remains the highly sensitive and reliable analysis of (endogenous) metabolites in especially volume-restricted samples. Moreover, there is a strong need for microscale analytical tools allowing chiral metabolomics studies, as chiral endogenous metabolites, such as for example D-amino acids and some D-organic acids, are more and more recognized as potential new biomarkers for the prediction and/or diagnosis of diseases. Therefore, the aim of this PhD project is to develop microscale analytical technologies for (chiral) metabolic profiling of especially small-volume biological samples. In this project, which is part of the Vidi-research program entitled "Enabling volume-restricted metabolomics using next-generation microscale analytical tools" from the Netherlands Organization for Scientific Research (NWO), capillary electrophoresis-mass spectrometry (CE-MS) will be considered as the main analytical platform for volume-restricted metabolomics. CE-MS method development for (chiral) metabolic profiling including utility assessment for relevant biomedical/clinical applications will be performed in collaboration with various internal and external partners.

The PhD candidate is responsible for: The Faculty of Science is a world-class faculty where staff and students work together in a dynamic international environment. It is a faculty where personal and academic development are top priorities. Our people are committed to expand fundamental knowledge by curiosity and to look beyond the borders of their own discipline; their aim is to benefit science, and to contribute to addressing the major societal challenges of the future.

The research carried out at the Faculty of Science is very diverse, ranging from mathematics, information science, astronomy, physics, chemistry and bio-pharmaceutical sciences to biology and environmental sciences. The research activities are organised in eight institutes. These institutes offer eight bachelor's and twelve master's programs. The faculty has grown strongly in recent years and now has more than 1,300 staff and almost 4,000 students. We are located at the heart of Leiden's Bio Science Park, one of Europe's biggest science parks, where university and business life come together. The Leiden Academic Centre for Drug Research (LACDR) is a leading institute dedicate to world-class research and education in drug discovery and development. LACDR comprises a diverse and international team of 150 researchers and has organized its research and education around three divisions. This project is part of the Biomedical Microscale Analytics research group of Dr. Rawi Ramautar, Division of Systems Biomedicine and Pharmacology

We offer a one year term position with the possibility of three-year renewal after a positive evaluation. Salary rangefrom 2,266 to 2,897 gross per month (pay scale P, in accordance with the Collective Labour Agreement for Dutch Universities).

Leiden University offers an attractive benefits package with additional holiday (8%) and end-of-year bonuses (8.3 %), training and career development and sabbatical leave. Our individual choices model gives you some freedom to assemble your own set of terms and conditions. For international spouses we have set up a dual career programme. Candidates from outside the Netherlands may be eligible for a substantial tax break.

Leiden University is strongly committed to diversity within its community and especially welcomes applications from members of underrepresented groups.

If you are interested in this position, you can contact Dr. Rawi Ramautar, group leader Biomedical Microscale Analytics, Division of Systems Biomedicine and Pharmacology of the LACDR, email address

Your application should be addressed to Dr. Rawi Ramautar and must include: a two-page personal motivation letter, a digital copy of your MSc diploma/qualification, a CV including the names and contact details of two recent references. Please apply no later than 30 November 2018. Only complete applications will be considered.


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