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Mres + PhD Studentships in Cancer Biology Within The Cancer Research Uk Cambridge Centre

University of Cambridge, UK has an opening PhD position in bioinformatics. The funds for this fellowship are available for 4 years. Eligible candidates should submit the applications before December 01, 2018.

In 2018, the Cancer Research UK Cambridge Centre launched a new fully-funded innovative MRes + PhD programme (4 years), designed to give students a broad understanding of both the basic biology and the clinical management of the whole spectrum of malignant disease. This course also allows students to develop their own skills in experimental science as well as in project design and management. The CRUK Cambridge Centre is a dynamic collaboration of academic researchers, clinicians, and the pharmaceutical and biotech industries based in the Cambridge area. By being part of the Centre, students will have the opportunity to attend a number of lecture series, workshops and meetings aimed at facilitating and strengthening collaborations between complimentary disciplines and across different departments and institutes.

The first year MRes degree comprises two research rotations, a weekly Lectures in Cancer Biology & Medicine series, together with a week of intensive teaching in genomic medicine, and a one- to two-week placement in a patient-facing setting. The placement will enable insight into the rewards and challenges of cancer research and development of diagnostics and treatments. Project write-ups and development of a PhD proposal are also integral to the programme. Successful completion of the one-year MRes programme will lead directly on to a three-year PhD, usually in one of the rotation project host laboratories, which will allow in-depth study of a particular area of cancer biology.

Five CRUK Cambridge Centre MRes + PhD studentships are available for non-clinical applicants, to commence in October 2019.

Students will choose one of the following CRUK Cambridge Centre Programmes, within which they will then undertake their two MRes rotation projects (examples of which are listed below) and subsequent PhD research:

The use of Crispr scaring and scRNAseq to study cellular dynamics changes and cell fate decisions in TNBC Combined effects of rare alleles in breast cancer susceptibility genes Body composition and endometrial cancer risk

RNA helicases as genetic modifiers in ovarian cancer: a new link between the SWI/SNF complex and RNA processing Do nuclear functions underpin the oncogenic potential of the tyrosine kinase, ACK? Checkpoint control of DNA replication prevents mutagenesis in normal and cancer cells Regulators of the tumour suppressor gene beclin 1

Role of GNA13 in lymphoid malignancies Targeting oestrogen receptors in myeloproliferative neoplasms Identification of RNA binding protein required for Lymphoma cells survival and proliferation

Why are some neuroblastoma tumours resistant to differentiation? Development of treatment strategies for ALK-positive neuroblastoma based on drug repurposing and novel drug combinations Targeting the neuroblastoma oncoprotein, MYCN, using intracellular nanobodies

Please note that these projects have a quantitative and/or bioinformatics theme. Predicting treatment responses using in silico mechanistic models of cancer Characterisation of the mutational progression in gastrointestinal adenocarcinomas Network Modelling in Acute Leukaemias to determine critical nodes for maintenance of disease and as targets for therapy

Informal enquiries can be sent to graduateadmissions@crukcambridgecentre.org.uk

Fixed-term: The funds for this post are available for 4 years.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Please ensure that you upload a CV and statement of interest (this should include your first and second choice of PhD project from those offer, as well as confirming your eligibility to practice) in the Upload section of the online application. If you upload any additional documents that have not been requested, we will not be able to consider these as part of your application.

The closing date for receipt of applications is 01 December 2018.

Short-listed applicants will be invited to interview week commencing 14 January 2019. You will be interviewed by a panel of Principal Investigators from the CRUK Cambridge Centre and you will be given the opportunity to visit the relevant department(s) or institute(s) for your selected project. We strongly encourage informal interaction between short-listed candidates and the Principal Investigators and their laboratories before the formal interview.


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