Research Associate in Protein X-ray crystallography

Imperial College London has an opening postdoc position in n Protein X-ray crystallography. Citizens of any country are eligible to apply. The deadline for applying is 16/09/2018.

The Department of Life Sciences was the top ranked university department in the UK for research intensity in Biological Sciences in REF2014 (Times Higher Education), scoring 100% on our environment. We are seeking to recruit an outstanding structural biologist to contribute to an ongoing drug discovery project in the groups of Dr Ernesto Cota, Department of Life Sciences and Professor Edward Tate, Department of Chemistry funded by Cancer Research UK. The project focuses on structure-guided design of ligands against small GTPases, a validated but challenging set of targets. The research is backed by a robust combination of biophysical, biochemical and cellular assays. The project is supported by collaborations with structural and cell biologists at Imperial and the CRUK Beatson Institute (Glasgow).

You will be expected to take a leading role in fragment-based screening, in silico design, protein X-ray crystallography, protein- and ligand-based NMR, and biophysical (ITC, SPR, MST) and biochemical assays, integrating data generated by colleagues working on hit optimisation and hit-to-lead programmes using medicinal chemistry approaches. You will exploit both small molecule and peptide modalities as appropriate to the target class, and will take responsibility for mentoring junior biochemists/structural biologists in our research teams.

You must have:
- A PhD (or equivalent), preferably in protein x-ray crystallography.
- A strong research track record in protein X-ray structure determination preferably demonstrated by first author publications in international journals.
- Experience in the design and execution of workflow for structure determination of proteins, from molecular biology/biochemical experiments
- Experience in optimisation of protein-ligand interactions using biophysical techniques

You must also have:
- Excellent verbal and written communication skills, and be able to write clearly and succinctly for publication.
- Ability to relate well with others, form positive relationships with a wide range of people and to work as part of a team, as well as independently.
- Ability to develop and apply new concepts and have a creative approach to problem-solving

This is a full-time, fixed-term appointmentavailable for up to 12 months. Informal enquires can be made directly to Dr Ernesto Cota, Senior Lecturer in Department of Life Sciences, at


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