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Research Associate in Computer Simulations and Statistical Mechanics of Genome Organization

University Of Cambridge is delighted to offer a postdoc position. This fellowship is available for all students around the world. Applicants should apply before September 26, 2018.

Applications are invited for a postdoctoral position to develop computational approaches to study the formation of membrane-less compartments via liquid-liquid phase separation inside the Cell nucleus. The position is supported by an ERC Starting Grant and the Winton Programme for the Physics of Sustainability. The successful candidate will join the research group of Dr. Rosana Collepardo (collepardolab.org) based at the Maxwell Centre, Cavendish laboratory. The project is in collaboration with Professor Daan Frenkel at the Department of Chemistry.

Reading the genome is one thing – finding out how it functions, is something else altogether. The next big challenge to understand gene behaviour is deciphering (a) how the genome is organized in space and (b) how this organization influences its function. Research at the Collepardo group focuses on developing new computer simulation approaches, exploiting principles from physics, chemistry, computer science, and biology, to unravel the molecular mechanism that explain the connection between genome characteristics, organization and function (JACS, 2015 137:10205, PNAS 2014, 111:8061). This project, in collaboration with the group of Professor Daan Frenkel (Biophys. J, 2017, 112:683), will develop a new simulation approach to investigate the phase behaviour of heterogenous mixtures of nucleic acids and proteins occurring inside the Cell nucleus that give rise to the formation of membrane-less liquid-droplet compartments.

The successful candidate will have strong experience in molecular modelling and simulations and statistical mechanics and will hold a PhD/DPhil in physics, chemistry, quantitative biology, applied mathematics, or a closely related field, with a strong interest in biological systems.

The proposed research project will be particularly suitable for candidates who have experience in developing coarse-grained models, and/or in developing and applying Molecular Dynamics and/or Monte Carlo simulations to biomolecular systems or condensed matter systems.

Fixed-term: The funds for this post are available for 12 months in the first instance.

To apply online for this vacancy, please click on the ‘Apply’ button below. This will route you to the University’s Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please ensure that you upload your Curriculum Vitae (CV) including a list of publications and the contact details of at least two referees and a covering letter in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.


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