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Research Associate at University of Cambridge

A Postdoc position is available at University of Cambridge. All students regardless of citizenship are eligible to apply. The deadline for applying is September 30, 2018.

Applications are invited for an enthusiastic, experienced and highly motivated Postdoctoral Research Associate interested in studying the role of chromatin remodelling in neural stem cell biology and paediatric brain tumour development using both in vitro and in vivo approaches. The work will be supervised by Dr Manav Pathania (Department of Pathology and CRUK Children’s Brain Tumour Centre of Excellence; https://crukcambridgecentre.org.uk/research/programmes/neuro-oncology/research-groups) and will be carried out in the Capella Building and the CRUK Cambridge Institute at the Addenbrooke’s Biomedical Campus.

Epigenomic deregulation is a hallmark feature of many distinct types of brain tumour and has been implicated in tumour heterogeneity and the development of resistance. Recently, we developed in vivo models of mutant histone-driven paediatric high-grade gliomas and discovered that these tumours develop specifically from embryonic neural progenitor cells (Pathania et al., Cancer Cell, 2017). We now seek an outstanding Postdoctoral Research Associate to help reveal how histone mutations rewire the epigenome to serve oncogenic programmes such as tumour initiation, tumour maintenance, heterogeneity and resistance to treatment. To do this, we will carefully characterise and interrogate these molecularly and histologically accurate in vivo models using developmental neurobiology, epigenetics, stem cell science and genomics approaches.

Applicants should have a PhD in a relevant subject, or be close to the completion of their degree. Candidates that have a strong background in the following three broad areas of expertise are encouraged to apply: (1) molecular biology, biochemistry, stem cell culture and FACS, (2) chromatin biology, library preparation, sequencing and basic genomics analysis (RNA-seq/ChIP-seq) and (3) histology/tissue processing, confocal microscopy, transgenics and mouse colony management. Knowledge of mammalian neurobiology or developmental biology is not necessary but would be very beneficial.

The successful applicant will have the opportunity to develop a basic science and multidisciplinary approach to translational cancer research. They will have a strong publication record and an excellent aptitude for research and career development. We are especially looking for applicants with a self-starter mentality, who combine a perceptive and resourceful approach with an ability to work independently. A proven capacity to design, execute, and interpret your own experiments is essential. The ability to think creatively and develop workaround approaches when faced with the challenges that may arise while conducting pioneering new research is highly desirable.

To apply online for this vacancy, please click on the ‘Apply’ button below. This will route you to the University’s Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Applications should include a CV with contact details for three references and a cover letter outlining reasons why you would like to be involved in the project, key areas of expertise and future goals/career ambitions. Informal enquiries can be addressed to Dr Manav Pathania (mp915@cam.ac.uk).

Any queries regarding the application process should be directed to hr@path.cam.ac.uk.


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