Research Assistant (Fixed Term)

University Of Cambridge is offering postdoc position. This fellowship is available for all students around the world. The deadline for applying is September 28, 2018.

Applications are invited for an efficient, organised and resourceful Research Assistant interested in studying the role of chromatin remodelling in neural stem cell biology and paediatric brain tumour development using both in vitro and in vivo approaches. The work will be supervised by Dr Manav Pathania (Department of Pathology and CRUK Children’s Brain Tumour Centre of Excellence; and will be carried out in the Capella Building and the CRUK Cambridge Institute at the Addenbrooke’s Biomedical Campus.

Epigenomic deregulation is a hallmark feature of many distinct types of brain tumour and has been implicated in tumour heterogeneity and the development of resistance. Recently, we developed in vivo models of mutant histone-driven paediatric high-grade gliomas and discovered that these tumours develop specifically from embryonic neural progenitor cells (Pathania et al., Cancer Cell, 2017). We now seek a Research Assistant to help reveal how histone mutations rewire the epigenome to serve oncogenic programmes such as tumour initiation, tumour maintenance, heterogeneity and resistance to treatment. To do this, we will carefully characterise and interrogate these molecularly and histologically accurate in vivo models using developmental neurobiology, epigenetics, stem cell science and genomics approaches.

Applicants should have a BSc/BA or MSc in a relevant subject, or be close to the completion of their degree. The role entails assisting with in vitro and in vivo research, establishing and implementing standard operating procedures and managing the day-to-day functioning of the lab. The successful candidate will have joint responsibility with the group leader for (1) reagent procurement and equipment maintenance, (2) health and safety, and (3) the provision of training and support to other members of the lab. Expertise in molecular biology, biochemistry, cell culture and mouse colony management will be necessary for securing this position. This role will necessitate broad involvement in all aspects of ongoing science in the lab, including both in vivo work in mice and cell culture, and is ideal for someone who is interested in a hands-on approach to science and working collaboratively. Working on an individual research project with support from other members of the lab will also be encouraged. We are especially looking for applicants who are careful, practical and enjoy working in a team.

Applications should include a CV with contact details for three references and a cover letter outlining reasons why you would like to be involved in the project, key areas of expertise and future goals/career ambitions. Informal enquiries can be addressed to Dr Manav Pathania ( Please quote reference PK16466 on your application and in any correspondence about this vacancy.

To apply online for this vacancy, please click on the ‘Apply’ button below. This will route you to the University’s Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please quote reference PK16466 on your application and in any correspondence about this vacancy.

Any queries regarding the application process should be directed to

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