Research Assistant at Imperial College London

A postdoc position is available at Imperial College London. Citizens of any country are eligible to apply. Applicants should apply before September 30, 2018.

The Department of Life Sciences was the top ranked university department in the UK for research intensity in Biological Sciences in REF2014 (Times Higher Education), scoring 100% on our environment.

A Research Assistant position is available to join the laboratory of Professor Gloria Rudenko in the Department of Life Sciences. You will be based at the South Kensington Campus of Imperial College London.

The research programme studies the molecular and cellular biology of African trypanosomes (causative agent of African Sleeping Sickness), particularly with regards to mechanisms mediating immune evasion. In particular, the group is interested in the epigenetic control of gene expression. Trypanosomes are single-celled eukaryotes capable of continuously changing their Variant Surface Glycoprotein (VSG) coat during the course of a chronic infection. Trypanosomes provide a very manipulable experimental system for investigating antigenic variation and host-pathogen interactions. We are attempting to understand how immune evasion operates through molecular approaches including genetic modification (gene knock-outs) and double-stranded RNA inhibition (RNAi).

A main focus of the group is understanding transcriptional control in trypanosomes, particularly with regards to how this is influenced by chromatin structure. African trypanosomes are effective extracellular parasites of the mammalian bloodstream, as they are protected by a dense Variant Surface Glycoprotein (VSG) coat which can be switched during the course of an infection. The active VSG gene is located in one of many VSG expression site transcription units. We would like to understand how VSG expression sites are turned on and off. In addition, we would like to understand how silent areas of the trypanosome genome are kept inactive, and how transcriptional control, including the epigenetic control of VSG expression is mediated (Mol Micro 2017 106(4): 614-634). Additional interests in the lab include the monitoring of VSG synthesis during the cell-cycle (Traffic 2018 19(6):391-405). Additional information about our research programme is available on our lab website:
- Perform experiments and interpret research results
- Prioritise tasks within agreed work schedule
- To maintain accurate and complete records of all findings
- To assist with the presentation of findings to colleagues and at conferences
- To assist in the drafting of publications for submission to refereed journals
- A BSc (or equivalent) in Biochemistry or Molecular Biology

You must be able to demonstrate experience in:
- Investigating basic molecular biology questions in any experimental system.
- A range of basic molecular biology techniques preferably including: DNA cloning, DNA and RNA analysis, Nucleic acid and protein analysis and sterile cell culture and transfection, PCR, qPCR and immunofluorescence microscopy.

You must also be able to demonstrate:
- Experience of working in a team
- The ability to develop and apply new concepts and have a creative approach to problem-solving.
- Excellent verbal and written communication skills
- The ability to organise your own work with minimal supervision and prioritise in response to deadlines.

This is a full,time fixed term position for one year.

For informal enquiries, please contact Professor Gloria Rudenko via email at .

Should you have any queries about the application process please contact Peggy Baker by email at and refer to the job reference number NAT00265.

For technical queries when applying online, please contact .

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College's care are treated with full respect, and that all staff involved with this work show due consideration at every level.


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