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Postdoc Position at University of Cambridge

University of Cambridge is pleased to invite applicants to apply for a postdoctoral fellowship position in biochemistry. This position is available for 6 months. Potential candidates should apply before October 31, 2018.

A short-term postdoctoral position is available for a cell biologist working on a joint BBSRC-funded project between Dr Katherine Stott of the Department of Biochemistry, University of Cambridge, Central Cambridge, and Professor Peter McNaughton, of King’s College London. Previous work in our labs has identified the interaction between the ion channel TRPV1 and a kinase anchoring protein (AKAP79) as a target for developing novel analgesics:

Btesh, J., Fischer, M. J., Stott, K. & McNaughton, P. A. Mapping the Binding Site of TRPV1 on AKAP79: Implications for Inflammatory Hyperalgesia. J. Neurosci. 33, 9184-9193 (2013).

The aim of the project is now to develop a cell-based assay to allow high-throughput screening for novel inhibitors, alongside a parallel project to enhance our knowledge of the structural biology of the interaction to aid in rational inhibitor design. Suitable candidates will have cell biology experience, e.g. heterologous protein expression in HEK or CHO cells. Prior experience of PPI reporter assay technologies such as split luciferase/NanoBiT would be useful, but not essential as full training will be given (https://www.promega.co.uk/resources/technologies/nanoluc-luciferase-redefining-reporter-assays/protein-protein-interactions/).

Candidates must either hold or be about to be awarded a PhD. The post-holder will be Cambridge-based, and will work closely with other members of the team who specialise in biochemistry, biophysics and structural biology.

Fixed-term: The funds for this post are available for 6 months in the first instance.

Informal enquiries can be made to Katherine Stott at ks123@cam.ac.uk.

Any enquiries relating to the application process can be directed to the HR team at personnel@bioc.cam.ac.uk.


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