Postdoc Position at Harvard Medical School

A postdoc position is available in health sciences at Harvard Medical School. Citizens of any country are eligible to apply. The deadline for applying is February 06, 2015. 

The Center for Interdisciplinary Cardiovascular Sciences (CICS; Director: Masanori Aikawa, MD, PhD) at the Brigham and Women ’s Hospital (BWH), a Harvard-affiliated hospital, is seeking a postdoctoral research fellow to contribute to its bioinformatics program within the Proteomics Research Group (Director: Sasha Singh, PhD).

The Proteomics team integrates mass spectrometry guided research into various cardiovascular disease-related sub-disciplines at CICS, including:
1) macrophage biology and lipid metabolism,
2) calcification in atherosclerosis and calcific aortic valve stenosis, and
3) the pathophysiology of metabolic diseases such as type II diabetes.

We launched CICS in collaboration with Kowa Company Ltd, a Japanese pharmaceutical company. This academia-industry collaboration develops and utilizes state-of-the-art platforms that in part rely on mass spectrometry based strategies for drug target discovery research.

We conduct interdisciplinary, team-driven research with scientists from BWH and Kowa working together in a shared space. Our intent is to establish a diverse, active and innovative working environment. We thus seek a highly motivated candidate with excellent interpersonal skills. CICS occupies a fully-equipped 25,000-sq. ft. space on the 17th floor of the Center for Life Sciences in the Longwood Medical Area, the heart of Boston ’s medical and research community. The Proteomics team has integrated into the CICS cardiovascular program the most current technologies available for qualitative and quantitative bottom-up mass spectrometry using high resolution and high accuracy instrument platforms.

Our research scope includes global proteome profiling using isobaric tandem mass tags or stable isotope labeling in culture, and targeted methods using both label-free and stable isotope conditions. In addition, we are applying a variety of quantitative MS strategies and mathematical modeling approaches for in vivo kinetics studies.

We are seeking individuals to collaborate with biologists on three major endeavors: 1) global proteomics data analysis; 2) establishing post-translational modification identification/characterization workflows, such as those pertaining to phosphorylation, glycosylation and ribosylation; and 3) expanding on current targeted proteomics workflows. Additional projects that would interest the candidate include transcription-based data analysis such as single-cell transcript profiling and systems biology/network analysis aimed to predict the benefits and off-target effects of putative therapeutics. The successful candidate will be able to collaborate with a number of talented researchers, will guide them through their research endeavors and will be a co-author on publications arising from these projects.

Application Requirements
The candidate must have a PhD or equivalent experience. The candidate will help to expand a bioinformatics program for mass spectrometry based target discovery platforms. Specific skill requirements include data analysis with statistics, script languages such as Python, programming languages such as C, C++, C # or JAVA, and scripting in Linux/UNIX.

Experience with computational mass spectrometry analysis is preferred; however, basic knowledge of mass spectrometry or equivalent biochemistry will also be considered. Experience in systems biology is also advantageous. We also expect an individual with outstanding motivation and a firm commitment to productivity.

How to apply?
Please send your CV, an outline of your research interests, and names, phone numbers and email addresses of three references to Dr. William Terry.

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